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Restoring striatal WAVE-1 improves maze exploration performance of GluN1 knockdown mice

NMDA receptors are important for cognition and are implicated in neuropsychiatric disorders. GluN1 knockdown (GluN1KD) mice have reduced NMDA receptor levels, striatal spine density deficits, and cognitive impairments. However, how NMDA depletion leads to these effects is unclear. Since Rho GTPases...

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Detalles Bibliográficos
Autores principales:	Chen, Yuxiao, Milenkovic, Marija, Horsfall, Wendy, Salahpour, Ali, Soderling, Scott H., Ramsey, Amy J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6198945/ https://www.ncbi.nlm.nih.gov/pubmed/30352064 http://dx.doi.org/10.1371/journal.pone.0199341

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