Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo

Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on th...

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Detalles Bibliográficos
Autores principales: Zhang, Wanglinhan, Zhang, Linlin, Gao, Huiling, Yang, Wenyan, Wang, Shuai, Xing, Lili, Xue, Xinyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199078/
https://www.ncbi.nlm.nih.gov/pubmed/30393681
http://dx.doi.org/10.1007/s40820-017-0185-x
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author Zhang, Wanglinhan
Zhang, Linlin
Gao, Huiling
Yang, Wenyan
Wang, Shuai
Xing, Lili
Xue, Xinyu
author_facet Zhang, Wanglinhan
Zhang, Linlin
Gao, Huiling
Yang, Wenyan
Wang, Shuai
Xing, Lili
Xue, Xinyu
author_sort Zhang, Wanglinhan
collection PubMed
description Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-017-0185-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-61990782018-11-02 Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo Zhang, Wanglinhan Zhang, Linlin Gao, Huiling Yang, Wenyan Wang, Shuai Xing, Lili Xue, Xinyu Nanomicro Lett Article Implantable bioelectronics for analyzing physiological biomarkers has recently been recognized as a promising technique in medical treatment or diagnostics. In this study, we developed a self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo. Based on the piezo-enzymatic-reaction coupling effect of GOx@ZnO nanowire, the device under an applied deformation can actively output piezoelectric signal containing the glucose-detecting information. No external electricity power source or battery is needed for this device, and the outputting piezoelectric voltage acts as both the biosensing signal and electricity power. A practical application of the skin-like glucometer implanted in mouse body for detecting blood glucose level has been simply demonstrated. These results provide a new technique path for diabetes prophylaxis and treatment. [Image: see text] ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s40820-017-0185-x) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2018-01-04 /pmc/articles/PMC6199078/ /pubmed/30393681 http://dx.doi.org/10.1007/s40820-017-0185-x Text en © The Author(s) 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Article
Zhang, Wanglinhan
Zhang, Linlin
Gao, Huiling
Yang, Wenyan
Wang, Shuai
Xing, Lili
Xue, Xinyu
Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title_full Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title_fullStr Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title_full_unstemmed Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title_short Self-Powered Implantable Skin-Like Glucometer for Real-Time Detection of Blood Glucose Level In Vivo
title_sort self-powered implantable skin-like glucometer for real-time detection of blood glucose level in vivo
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199078/
https://www.ncbi.nlm.nih.gov/pubmed/30393681
http://dx.doi.org/10.1007/s40820-017-0185-x
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