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Human VMPFC encodes early signatures of confidence in perceptual decisions
Choice confidence, an individual’s internal estimate of judgment accuracy, plays a critical role in adaptive behaviour, yet its neural representations during decision formation remain underexplored. Here, we recorded simultaneous EEG-fMRI while participants performed a direction discrimination task...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
eLife Sciences Publications, Ltd
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199131/ https://www.ncbi.nlm.nih.gov/pubmed/30247123 http://dx.doi.org/10.7554/eLife.38293 |
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author | Gherman, Sabina Philiastides, Marios G. |
author_facet | Gherman, Sabina Philiastides, Marios G. |
author_sort | Gherman, Sabina |
collection | PubMed |
description | Choice confidence, an individual’s internal estimate of judgment accuracy, plays a critical role in adaptive behaviour, yet its neural representations during decision formation remain underexplored. Here, we recorded simultaneous EEG-fMRI while participants performed a direction discrimination task and rated their confidence on each trial. Using multivariate single-trial discriminant analysis of the EEG, we identified a stimulus-independent component encoding confidence, which appeared prior to subjects’ explicit choice and confidence report, and was consistent with a confidence measure predicted by an accumulation-to-bound model of decision-making. Importantly, trial-to-trial variability in this electrophysiologically-derived confidence signal was uniquely associated with fMRI responses in the ventromedial prefrontal cortex (VMPFC), a region not typically associated with confidence for perceptual decisions. Furthermore, activity in the VMPFC was functionally coupled with regions of the frontal cortex linked to perceptual decision-making and metacognition. Our results suggest that the VMPFC holds an early confidence representation arising from decision dynamics, preceding and potentially informing metacognitive evaluation. |
format | Online Article Text |
id | pubmed-6199131 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | eLife Sciences Publications, Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61991312018-11-05 Human VMPFC encodes early signatures of confidence in perceptual decisions Gherman, Sabina Philiastides, Marios G. eLife Neuroscience Choice confidence, an individual’s internal estimate of judgment accuracy, plays a critical role in adaptive behaviour, yet its neural representations during decision formation remain underexplored. Here, we recorded simultaneous EEG-fMRI while participants performed a direction discrimination task and rated their confidence on each trial. Using multivariate single-trial discriminant analysis of the EEG, we identified a stimulus-independent component encoding confidence, which appeared prior to subjects’ explicit choice and confidence report, and was consistent with a confidence measure predicted by an accumulation-to-bound model of decision-making. Importantly, trial-to-trial variability in this electrophysiologically-derived confidence signal was uniquely associated with fMRI responses in the ventromedial prefrontal cortex (VMPFC), a region not typically associated with confidence for perceptual decisions. Furthermore, activity in the VMPFC was functionally coupled with regions of the frontal cortex linked to perceptual decision-making and metacognition. Our results suggest that the VMPFC holds an early confidence representation arising from decision dynamics, preceding and potentially informing metacognitive evaluation. eLife Sciences Publications, Ltd 2018-09-24 /pmc/articles/PMC6199131/ /pubmed/30247123 http://dx.doi.org/10.7554/eLife.38293 Text en © 2018, Gherman et al http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Neuroscience Gherman, Sabina Philiastides, Marios G. Human VMPFC encodes early signatures of confidence in perceptual decisions |
title | Human VMPFC encodes early signatures of confidence in perceptual decisions |
title_full | Human VMPFC encodes early signatures of confidence in perceptual decisions |
title_fullStr | Human VMPFC encodes early signatures of confidence in perceptual decisions |
title_full_unstemmed | Human VMPFC encodes early signatures of confidence in perceptual decisions |
title_short | Human VMPFC encodes early signatures of confidence in perceptual decisions |
title_sort | human vmpfc encodes early signatures of confidence in perceptual decisions |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199131/ https://www.ncbi.nlm.nih.gov/pubmed/30247123 http://dx.doi.org/10.7554/eLife.38293 |
work_keys_str_mv | AT ghermansabina humanvmpfcencodesearlysignaturesofconfidenceinperceptualdecisions AT philiastidesmariosg humanvmpfcencodesearlysignaturesofconfidenceinperceptualdecisions |