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Cysteine residues contribute to the dimerization and enzymatic activity of human nuclear dUTP nucleotidohydrolase (nDut)

dUTPase is an enzyme found in all organisms that have thymine as a constituent of DNA. Through evolution, humans have two major isoforms of dUTPase: a mitochondrial (mDut) and a nuclear (nDut) isoform. The nuclear isoform of dUTPase is a 164‐amino‐acids‐long protein containing three cysteine residue...

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Detalles Bibliográficos
Autores principales:	Rotoli, Shawna M., Jones, Julia L., Caradonna, Salvatore J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2018
Materias:	Full‐Length Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199149/ https://www.ncbi.nlm.nih.gov/pubmed/30052299 http://dx.doi.org/10.1002/pro.3481

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