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SAC3D1: a novel prognostic marker in hepatocellular carcinoma
Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated i...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199250/ https://www.ncbi.nlm.nih.gov/pubmed/30353105 http://dx.doi.org/10.1038/s41598-018-34129-9 |
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author | Han, Myoung-Eun Kim, Ji-Young Kim, Ga Hyun Park, Si Young Kim, Yun Hak Oh, Sae-Ock |
author_facet | Han, Myoung-Eun Kim, Ji-Young Kim, Ga Hyun Park, Si Young Kim, Yun Hak Oh, Sae-Ock |
author_sort | Han, Myoung-Eun |
collection | PubMed |
description | Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated in hepatocellular carcinoma (HCC). In this study, 3 independent cohorts (GSE10186, n = 80; TCGA, n = 330 and ICGC, n = 237) were used to assess SAC3D1 as a biomarker, which demonstrated SAC3D1 overexpression in HCC tissues when compared to the matched normal tissues. Kaplan-Meier survival analysis also showed that its overexpression was associated with poor prognosis of HCC with good discriminative ability in 3 independent cohorts (GSE10186, P = 0.00469; TCGA, P = 0.0000413 and ICGC, P = 0.0000114). Analysis of the C-indices and AUC values further supported its discriminative ability. Finally, multivariate analysis confirmed its prognostic significance (GSE10186, P = 0.00695; TCGA, P = 0.0000289 and ICGC, P = 0.0000651). These results suggest a potential of SAC3D1 as a biomarker for HCC. |
format | Online Article Text |
id | pubmed-6199250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-61992502018-10-25 SAC3D1: a novel prognostic marker in hepatocellular carcinoma Han, Myoung-Eun Kim, Ji-Young Kim, Ga Hyun Park, Si Young Kim, Yun Hak Oh, Sae-Ock Sci Rep Article Centrosome-associated proteins are recognized as prognostic factors in many cancers because centrosomes are critical structures for the cell cycle progression and genomic stability. SAC3D1, however, is associated with centrosome abnormality, although its prognostic potential has not been evaluated in hepatocellular carcinoma (HCC). In this study, 3 independent cohorts (GSE10186, n = 80; TCGA, n = 330 and ICGC, n = 237) were used to assess SAC3D1 as a biomarker, which demonstrated SAC3D1 overexpression in HCC tissues when compared to the matched normal tissues. Kaplan-Meier survival analysis also showed that its overexpression was associated with poor prognosis of HCC with good discriminative ability in 3 independent cohorts (GSE10186, P = 0.00469; TCGA, P = 0.0000413 and ICGC, P = 0.0000114). Analysis of the C-indices and AUC values further supported its discriminative ability. Finally, multivariate analysis confirmed its prognostic significance (GSE10186, P = 0.00695; TCGA, P = 0.0000289 and ICGC, P = 0.0000651). These results suggest a potential of SAC3D1 as a biomarker for HCC. Nature Publishing Group UK 2018-10-23 /pmc/articles/PMC6199250/ /pubmed/30353105 http://dx.doi.org/10.1038/s41598-018-34129-9 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Han, Myoung-Eun Kim, Ji-Young Kim, Ga Hyun Park, Si Young Kim, Yun Hak Oh, Sae-Ock SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title | SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title_full | SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title_fullStr | SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title_full_unstemmed | SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title_short | SAC3D1: a novel prognostic marker in hepatocellular carcinoma |
title_sort | sac3d1: a novel prognostic marker in hepatocellular carcinoma |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199250/ https://www.ncbi.nlm.nih.gov/pubmed/30353105 http://dx.doi.org/10.1038/s41598-018-34129-9 |
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