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Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study

Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chroni...

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Autores principales: Fan, Lu, Sun, Ya-Bin, Sun, Ze-Kun, Wang, Ning, Luo, Fei, Yu, Feng, Wang, Jin-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199271/
https://www.ncbi.nlm.nih.gov/pubmed/30353114
http://dx.doi.org/10.1038/s41598-018-34099-y
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author Fan, Lu
Sun, Ya-Bin
Sun, Ze-Kun
Wang, Ning
Luo, Fei
Yu, Feng
Wang, Jin-Yan
author_facet Fan, Lu
Sun, Ya-Bin
Sun, Ze-Kun
Wang, Ning
Luo, Fei
Yu, Feng
Wang, Jin-Yan
author_sort Fan, Lu
collection PubMed
description Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs). The TN patients were found to have stronger attenuation of the MMN at longer ISIs than HCs. Correlation analysis revealed a significant positive correlation between the sensory subscale of McGill Pain Questionnaire and MMN amplitude reduction across ISI conditions. In experiment 2, MMNs recorded before, during, and after the cold pressor test were compared in healthy subjects. MMN amplitude was significantly reduced during pain exposure and recovered immediately thereafter. These results suggest that both chronic pain and acute pain can interfere with automatic change detection processes in the brain. This study provides the first evidence that chronic pain patients have a faster auditory memory trace decay than HCs.
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spelling pubmed-61992712018-10-25 Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study Fan, Lu Sun, Ya-Bin Sun, Ze-Kun Wang, Ning Luo, Fei Yu, Feng Wang, Jin-Yan Sci Rep Article Pain, especially chronic pain, can lead to cognitive deficits. Mismatch negativity (MMN) is a change-specific component of the auditory event-related brain potential (ERP) that is thought to provide a unique window into sensory memory processes. The present study was designed to determine how chronic and acute pain affects auditory sensory memory. In experiment 1, MMNs elicited by standard and deviant auditory stimuli at short and long inter-stimulus intervals (ISIs) were compared between trigeminal neuralgia (TN) patients and demographically matched healthy controls (HCs). The TN patients were found to have stronger attenuation of the MMN at longer ISIs than HCs. Correlation analysis revealed a significant positive correlation between the sensory subscale of McGill Pain Questionnaire and MMN amplitude reduction across ISI conditions. In experiment 2, MMNs recorded before, during, and after the cold pressor test were compared in healthy subjects. MMN amplitude was significantly reduced during pain exposure and recovered immediately thereafter. These results suggest that both chronic pain and acute pain can interfere with automatic change detection processes in the brain. This study provides the first evidence that chronic pain patients have a faster auditory memory trace decay than HCs. Nature Publishing Group UK 2018-10-23 /pmc/articles/PMC6199271/ /pubmed/30353114 http://dx.doi.org/10.1038/s41598-018-34099-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fan, Lu
Sun, Ya-Bin
Sun, Ze-Kun
Wang, Ning
Luo, Fei
Yu, Feng
Wang, Jin-Yan
Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title_full Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title_fullStr Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title_full_unstemmed Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title_short Modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
title_sort modulation of auditory sensory memory by chronic clinical pain and acute experimental pain: a mismatch negativity study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199271/
https://www.ncbi.nlm.nih.gov/pubmed/30353114
http://dx.doi.org/10.1038/s41598-018-34099-y
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