Design of Peptoid-peptide Macrocycles to Inhibit the β-catenin TCF Interaction in Prostate Cancer

New chemical inhibitors of protein–protein interactions are needed to propel advances in molecular pharmacology. Peptoids are peptidomimetic oligomers with the capability to inhibit protein-protein interactions by mimicking protein secondary structure motifs. Here we report the in silico design of a...

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Detalles Bibliográficos
Autores principales: Schneider, Jeffrey A., Craven, Timothy W., Kasper, Amanda C., Yun, Chi, Haugbro, Michael, Briggs, Erica M., Svetlov, Vladimir, Nudler, Evgeny, Knaut, Holger, Bonneau, Richard, Garabedian, Michael J., Kirshenbaum, Kent, Logan, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199279/
https://www.ncbi.nlm.nih.gov/pubmed/30352998
http://dx.doi.org/10.1038/s41467-018-06845-3

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