Cargando…
The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development
The Mst1 and 2 cytosolic serine/threonine protein kinases are the mammalian orthologs of the Drosophila Hippo protein. Mst1 has been shown previously to participate in T-cell and B-cell trafficking and the migration of lymphocytes into secondary lymphoid organs in a cell intrinsic manner. We show he...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199389/ https://www.ncbi.nlm.nih.gov/pubmed/30386341 http://dx.doi.org/10.3389/fimmu.2018.02393 |
_version_ | 1783365136320299008 |
---|---|
author | Alsufyani, Faisal Mattoo, Hamid Zhou, Dawang Cariappa, Annaiah Van Buren, Denille Hock, Hanno Avruch, Joseph Pillai, Shiv |
author_facet | Alsufyani, Faisal Mattoo, Hamid Zhou, Dawang Cariappa, Annaiah Van Buren, Denille Hock, Hanno Avruch, Joseph Pillai, Shiv |
author_sort | Alsufyani, Faisal |
collection | PubMed |
description | The Mst1 and 2 cytosolic serine/threonine protein kinases are the mammalian orthologs of the Drosophila Hippo protein. Mst1 has been shown previously to participate in T-cell and B-cell trafficking and the migration of lymphocytes into secondary lymphoid organs in a cell intrinsic manner. We show here that the absence of Mst1 alone only modestly impacts B cell homing to lymph nodes. The absence of both Mst1 and 2 in hematopoietic cells results in relatively normal B cell development in the bone marrow and does not impact migration of immature B cells to the spleen. However, follicular B cells lacking both Mst1 and Mst2 mature in the splenic white pulp but are unable to recirculate to lymph nodes or to the bone marrow. These cells also cannot traffic efficiently to the splenic red pulp. The inability of late transitional and follicular B cells lacking Mst 1 and 2 to migrate to the red pulp explains their failure to differentiate into marginal zone B cell precursors and marginal zone B cells. Mst1 and Mst2 are therefore required for follicular B cells to acquire the ability to recirculate and also to migrate to the splenic red pulp in order to generate marginal zone B cells. In addition B-1 a B cell development is defective in the absence of Mst1. |
format | Online Article Text |
id | pubmed-6199389 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-61993892018-11-01 The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development Alsufyani, Faisal Mattoo, Hamid Zhou, Dawang Cariappa, Annaiah Van Buren, Denille Hock, Hanno Avruch, Joseph Pillai, Shiv Front Immunol Immunology The Mst1 and 2 cytosolic serine/threonine protein kinases are the mammalian orthologs of the Drosophila Hippo protein. Mst1 has been shown previously to participate in T-cell and B-cell trafficking and the migration of lymphocytes into secondary lymphoid organs in a cell intrinsic manner. We show here that the absence of Mst1 alone only modestly impacts B cell homing to lymph nodes. The absence of both Mst1 and 2 in hematopoietic cells results in relatively normal B cell development in the bone marrow and does not impact migration of immature B cells to the spleen. However, follicular B cells lacking both Mst1 and Mst2 mature in the splenic white pulp but are unable to recirculate to lymph nodes or to the bone marrow. These cells also cannot traffic efficiently to the splenic red pulp. The inability of late transitional and follicular B cells lacking Mst 1 and 2 to migrate to the red pulp explains their failure to differentiate into marginal zone B cell precursors and marginal zone B cells. Mst1 and Mst2 are therefore required for follicular B cells to acquire the ability to recirculate and also to migrate to the splenic red pulp in order to generate marginal zone B cells. In addition B-1 a B cell development is defective in the absence of Mst1. Frontiers Media S.A. 2018-10-17 /pmc/articles/PMC6199389/ /pubmed/30386341 http://dx.doi.org/10.3389/fimmu.2018.02393 Text en Copyright © 2018 Alsufyani, Mattoo, Zhou, Cariappa, Van Buren, Hock, Avruch and Pillai. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Alsufyani, Faisal Mattoo, Hamid Zhou, Dawang Cariappa, Annaiah Van Buren, Denille Hock, Hanno Avruch, Joseph Pillai, Shiv The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title | The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title_full | The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title_fullStr | The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title_full_unstemmed | The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title_short | The Mst1 Kinase Is Required for Follicular B Cell Homing and B-1 B Cell Development |
title_sort | mst1 kinase is required for follicular b cell homing and b-1 b cell development |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199389/ https://www.ncbi.nlm.nih.gov/pubmed/30386341 http://dx.doi.org/10.3389/fimmu.2018.02393 |
work_keys_str_mv | AT alsufyanifaisal themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT mattoohamid themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT zhoudawang themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT cariappaannaiah themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT vanburendenille themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT hockhanno themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT avruchjoseph themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT pillaishiv themst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT alsufyanifaisal mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT mattoohamid mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT zhoudawang mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT cariappaannaiah mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT vanburendenille mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT hockhanno mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT avruchjoseph mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment AT pillaishiv mst1kinaseisrequiredforfollicularbcellhomingandb1bcelldevelopment |