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Urinary Bisphenol A Levels and Male Fertility
Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility an...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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SAGE Publications
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199454/ https://www.ncbi.nlm.nih.gov/pubmed/30261816 http://dx.doi.org/10.1177/1557988318799163 |
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author | Radwan, Michał Wielgomas, Bartosz Dziewirska, Emila Radwan, Paweł Kałużny, Paweł Klimowska, Anna Hanke, Wojciech Jurewicz, Joanna |
author_facet | Radwan, Michał Wielgomas, Bartosz Dziewirska, Emila Radwan, Paweł Kałużny, Paweł Klimowska, Anna Hanke, Wojciech Jurewicz, Joanna |
author_sort | Radwan, Michał |
collection | PubMed |
description | Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th–50th percentile and total sperm sex chromosome disomy (p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy (p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) (p = .018) and decrease motility (p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings. |
format | Online Article Text |
id | pubmed-6199454 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-61994542018-11-01 Urinary Bisphenol A Levels and Male Fertility Radwan, Michał Wielgomas, Bartosz Dziewirska, Emila Radwan, Paweł Kałużny, Paweł Klimowska, Anna Hanke, Wojciech Jurewicz, Joanna Am J Mens Health Original Articles Bisphenol A (BPA) is a high-production volume industrial chemical found in many consumer products. BPA is a suspected potent endocrine disruptor, with endocrine-disrupting properties demonstrated in animal studies. Few human studies have examined bisphenol A exposure in relation to male fertility and, results are divergent. The aim of the study is to examine the associations between urinary BPA concentration and male fertility. Bisphenol A urinary concentrations were measured using gas chromatography coupled with tandem mass spectrometry in 315 men under 45 years of age with normal sperm concentration (⩾15 mln/ml) recruited from a male reproductive health clinic. Participants were interviewed and provided a semen sample. BPA was detected in 98.10% of urine samples, with a median concentration of 1.87 µg/l (1.63 µg/ g creatinine). A multiple linear regression analysis identified a positive association between the urinary concentrations of bisphenol A 25th–50th percentile and total sperm sex chromosome disomy (p = .004). Also when modeled as continuous variable urinary BPA concentration increased total sperm sex chromosome disomy (p = .01). Urinary concentration of BPA also increase the percentage of immature sperm (HDS) (p = .018) and decrease motility (p = .03). The study provides evidence that exposure to BPA is associated with poorer semen quality. Future studies are needed to confirm these findings. SAGE Publications 2018-09-27 2018-11 /pmc/articles/PMC6199454/ /pubmed/30261816 http://dx.doi.org/10.1177/1557988318799163 Text en © The Author(s) 2018 http://www.creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Original Articles Radwan, Michał Wielgomas, Bartosz Dziewirska, Emila Radwan, Paweł Kałużny, Paweł Klimowska, Anna Hanke, Wojciech Jurewicz, Joanna Urinary Bisphenol A Levels and Male Fertility |
title | Urinary Bisphenol A Levels and Male Fertility |
title_full | Urinary Bisphenol A Levels and Male Fertility |
title_fullStr | Urinary Bisphenol A Levels and Male Fertility |
title_full_unstemmed | Urinary Bisphenol A Levels and Male Fertility |
title_short | Urinary Bisphenol A Levels and Male Fertility |
title_sort | urinary bisphenol a levels and male fertility |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199454/ https://www.ncbi.nlm.nih.gov/pubmed/30261816 http://dx.doi.org/10.1177/1557988318799163 |
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