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Inhibition of CCL3 abrogated precursor cell fusion and bone erosions in human osteoclast cultures and murine collagen-induced arthritis

OBJECTIVE: Macrophage inflammatory protein 1-alpha (CCL3) is a chemokine that regulates macrophage trafficking to the inflamed joint. The agonistic effect of CCL3 on osteolytic lesions in patients with multiple myeloma is recognized; however, its role in skeletal damage during inflammatory arthritis...

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Detalles Bibliográficos
Autores principales:	Jordan, Lauren A, Erlandsson, Malin C, Fenner, Benjamin F, Davies, Ruth, Harvey, Ann K, Choy, Ernest H, Errington, Rachel, Bokarewa, Maria I, Williams, Anwen S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2018
Materias:	Basic and Translational Science
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199535/ https://www.ncbi.nlm.nih.gov/pubmed/30053130 http://dx.doi.org/10.1093/rheumatology/key196

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