Cargando…

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants

OBJECTIVE: To evaluate the associations of a polygenic risk score and healthy lifestyle with incident stroke. DESIGN: Prospective population based cohort study. SETTING: UK Biobank Study, UK. PARTICIPANTS: 306 473 men and women, aged 40-73 years, recruited between 2006 and 2010. MAIN OUTCOME MEASURE...

Descripción completa

Detalles Bibliográficos
Autores principales:	Larsson, Susanna C, Malik, Rainer, Rannikmäe, Kristiina, Sudlow, Cathie L, Dichgans, Martin, Markus, Hugh S, Traylor, Matthew, Rutten-Jacobs, Loes CA
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group Ltd. 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199557/ https://www.ncbi.nlm.nih.gov/pubmed/30355576 http://dx.doi.org/10.1136/bmj.k4168

Ejemplares similares

Genetic Study of White Matter Integrity in UK Biobank (N=8448) and the Overlap With Stroke, Depression, and Dementia
por: Rutten-Jacobs, Loes C.A., et al.
Publicado: (2018)

Physician-Confirmed and Administrative Definitions of Stroke in UK Biobank Reflect the Same Underlying Genetic Trait
por: Rannikmäe, Kristiina, et al.
Publicado: (2022)

Developing automated methods for disease subtyping in UK Biobank: an exemplar study on stroke
por: Rannikmäe, Kristiina, et al.
Publicado: (2021)

Genome‐wide meta‐analysis identifies 3 novel loci associated with stroke
por: Malik, Rainer, et al.
Publicado: (2018)

Genetic Associations With White Matter Hyperintensities Confer Risk of Lacunar Stroke
por: Traylor, Matthew, et al.
Publicado: (2016)

Frequency and Phenotype Associations of Rare Variants in 5 Monogenic Cerebral Small Vessel Disease Genes in 200,000 UK Biobank Participants
por: Ferguson, Amy Christina, et al.
Publicado: (2022)

Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex
por: Traylor, Matthew, et al.
Publicado: (2015)

Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants
por: He, Karen Y., et al.
Publicado: (2023)

UK Biobank: opportunities for cardiovascular research
por: Littlejohns, Thomas J, et al.
Publicado: (2019)

Identifying dementia outcomes in UK Biobank: a validation study of primary care, hospital admissions and mortality data
por: Wilkinson, Tim, et al.
Publicado: (2019)

Common NOTCH3 Variants and Cerebral Small-Vessel Disease
por: Rutten-Jacobs, Loes C.A., et al.
Publicado: (2015)

Challenges of linking to routine healthcare records in UK Biobank
por: Adamska, Ligia, et al.
Publicado: (2015)

Testosterone and socioeconomic position: Mendelian randomization in 306,248 men and women in UK Biobank
por: Harrison, Sean, et al.
Publicado: (2021)

Modifiable pathways in Alzheimer’s disease: Mendelian randomisation analysis
por: Larsson, Susanna C, et al.
Publicado: (2017)

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype
por: Rutten-Jacobs, Loes C.A., et al.
Publicado: (2016)

Accuracy of identifying incident stroke cases from linked health care data in UK Biobank
por: Rannikmäe, Kristiina, et al.
Publicado: (2020)

Accuracy of Patient Self-Report of Stroke: A Systematic Review from the UK Biobank Stroke Outcomes Group
por: Woodfield, Rebecca, et al.
Publicado: (2015)

Central adiposity and the overweight risk paradox in aging: follow-up of 130,473 UK Biobank participants
por: Bowman, Kirsty, et al.
Publicado: (2017)

Algorithms for the Capture and Adjudication of Prevalent and Incident Diabetes in UK Biobank
por: Eastwood, Sophie V, et al.
Publicado: (2016)

Identification and validation of myocardial infarction and stroke outcomes at scale in UK Biobank
por: Schnier, Christian, et al.
Publicado: (2017)

Genetic variation in PLEKHG1 is associated with white matter hyperintensities (n = 11,226)
por: Traylor, Matthew, et al.
Publicado: (2019)

Comparison of Sociodemographic and Health-Related Characteristics of UK Biobank Participants With Those of the General Population
por: Fry, Anna, et al.
Publicado: (2017)

Accuracy of Electronic Health Record Data for Identifying Stroke Cases in Large-Scale Epidemiological Studies: A Systematic Review from the UK Biobank Stroke Outcomes Group
por: Woodfield, Rebecca, et al.
Publicado: (2015)

Genetics of stroke in a UK African ancestry case-control study: South London Ethnicity and Stroke Study
por: Traylor, Matthew, et al.
Publicado: (2017)

Cohort profile: design and methods in the eye and vision consortium of UK Biobank
por: Chua, Sharon Yu Lin, et al.
Publicado: (2019)

Broad phenotype of cysteine-altering NOTCH3 variants in UK Biobank: CADASIL to nonpenetrance
por: Rutten, Julie W., et al.
Publicado: (2020)

Reproducible disease phenotyping at scale: Example of coronary artery disease in UK Biobank
por: Patel, Riyaz S., et al.
Publicado: (2022)

Interleukin-6 Signaling Effects on Ischemic Stroke and Other Cardiovascular Outcomes: A Mendelian Randomization Study
por: Georgakis, Marios K., et al.
Publicado: (2020)

Causal Impact of Type 2 Diabetes Mellitus on Cerebral Small Vessel Disease: A Mendelian Randomization Analysis
por: Liu, Junfeng, et al.
Publicado: (2018)

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke
por: Rutten-Jacobs, Loes C.A., et al.
Publicado: (2017)

Suitability of UK Biobank Retinal Images for Automatic Analysis of Morphometric Properties of the Vasculature
por: MacGillivray, Thomas J, et al.
Publicado: (2015)

Benchmarking network-based gene prioritization methods for cerebral small vessel disease
por: Zhang, Huayu, et al.
Publicado: (2021)

Identifying dementia cases with routinely collected health data: A systematic review
por: Wilkinson, Tim, et al.
Publicado: (2018)

Accuracy of routinely-collected healthcare data for identifying motor neurone disease cases: A systematic review
por: Horrocks, Sophie, et al.
Publicado: (2017)

Drug prescriptions and dementia incidence: a medication-wide association study of 17000 dementia cases among half a million participants
por: Wilkinson, Tim, et al.
Publicado: (2022)

Rare variants of the 3’-5’ DNA exonuclease TREX1 in early onset small vessel stroke
por: McGlasson, Sarah, et al.
Publicado: (2017)

ukbtools: An R package to manage and query UK Biobank data
por: Hanscombe, Ken B., et al.
Publicado: (2019)

Modifiable Lifestyle Factors and Risk of Stroke: A Mendelian Randomization Analysis
por: Harshfield, Eric L., et al.
Publicado: (2021)

Identifying Parkinson's disease and parkinsonism cases using routinely collected healthcare data: A systematic review
por: Harding, Zoe, et al.
Publicado: (2019)

Emergency personnel neuroticism, health and lifestyle: A UK Biobank study
por: Mutambudzi, M, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_f5qq4upmjrfkguel98b0u5hh5o