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PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Korean Society for Molecular and Cellular Biology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199570/ https://www.ncbi.nlm.nih.gov/pubmed/30352491 http://dx.doi.org/10.14348/molcells.2018.0192 |
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author | Kim, Do-Hyoung Han, Kyou-Hoon |
author_facet | Kim, Do-Hyoung Han, Kyou-Hoon |
author_sort | Kim, Do-Hyoung |
collection | PubMed |
description | Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pandemics. Pre-structured motifs (PreSMos) refer to transient local secondary structural elements present in the target-unbound state of IDPs. During the last two decades PreSMos have been steadily acknowledged as the critical determinants for target binding in dozens of IDPs. To date, the PreSMo concept provides the most convincing structural rationale explaining the IDP-target binding behavior at an atomic resolution. Here we present a brief developmental history of PreSMos and describe their common characteristics. We also provide a list of newly discovered PreSMos along with their functional relevance. |
format | Online Article Text |
id | pubmed-6199570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61995702018-11-08 PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins Kim, Do-Hyoung Han, Kyou-Hoon Mol Cells Minireview Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pandemics. Pre-structured motifs (PreSMos) refer to transient local secondary structural elements present in the target-unbound state of IDPs. During the last two decades PreSMos have been steadily acknowledged as the critical determinants for target binding in dozens of IDPs. To date, the PreSMo concept provides the most convincing structural rationale explaining the IDP-target binding behavior at an atomic resolution. Here we present a brief developmental history of PreSMos and describe their common characteristics. We also provide a list of newly discovered PreSMos along with their functional relevance. Korean Society for Molecular and Cellular Biology 2018-10-31 2018-10-10 /pmc/articles/PMC6199570/ /pubmed/30352491 http://dx.doi.org/10.14348/molcells.2018.0192 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Minireview Kim, Do-Hyoung Han, Kyou-Hoon PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title_full | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title_fullStr | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title_full_unstemmed | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title_short | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
title_sort | presmo target-binding signatures in intrinsically disordered proteins |
topic | Minireview |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199570/ https://www.ncbi.nlm.nih.gov/pubmed/30352491 http://dx.doi.org/10.14348/molcells.2018.0192 |
work_keys_str_mv | AT kimdohyoung presmotargetbindingsignaturesinintrinsicallydisorderedproteins AT hankyouhoon presmotargetbindingsignaturesinintrinsicallydisorderedproteins |