Cargando…

PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins

Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without...

Descripción completa

Detalles Bibliográficos
Autores principales: Kim, Do-Hyoung, Han, Kyou-Hoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199570/
https://www.ncbi.nlm.nih.gov/pubmed/30352491
http://dx.doi.org/10.14348/molcells.2018.0192
_version_ 1783365173860368384
author Kim, Do-Hyoung
Han, Kyou-Hoon
author_facet Kim, Do-Hyoung
Han, Kyou-Hoon
author_sort Kim, Do-Hyoung
collection PubMed
description Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pandemics. Pre-structured motifs (PreSMos) refer to transient local secondary structural elements present in the target-unbound state of IDPs. During the last two decades PreSMos have been steadily acknowledged as the critical determinants for target binding in dozens of IDPs. To date, the PreSMo concept provides the most convincing structural rationale explaining the IDP-target binding behavior at an atomic resolution. Here we present a brief developmental history of PreSMos and describe their common characteristics. We also provide a list of newly discovered PreSMos along with their functional relevance.
format Online
Article
Text
id pubmed-6199570
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Korean Society for Molecular and Cellular Biology
record_format MEDLINE/PubMed
spelling pubmed-61995702018-11-08 PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins Kim, Do-Hyoung Han, Kyou-Hoon Mol Cells Minireview Intrinsically disordered proteins (IDPs) are highly unorthodox proteins that do not form three-dimensional structures under physiological conditions. The discovery of IDPs has destroyed the classical structure-function paradigm in protein science, 3-D structure = function, because IDPs even without well-folded 3-D structures are still capable of performing important biological functions and furthermore are associated with fatal diseases such as cancers, neurodegenerative diseases and viral pandemics. Pre-structured motifs (PreSMos) refer to transient local secondary structural elements present in the target-unbound state of IDPs. During the last two decades PreSMos have been steadily acknowledged as the critical determinants for target binding in dozens of IDPs. To date, the PreSMo concept provides the most convincing structural rationale explaining the IDP-target binding behavior at an atomic resolution. Here we present a brief developmental history of PreSMos and describe their common characteristics. We also provide a list of newly discovered PreSMos along with their functional relevance. Korean Society for Molecular and Cellular Biology 2018-10-31 2018-10-10 /pmc/articles/PMC6199570/ /pubmed/30352491 http://dx.doi.org/10.14348/molcells.2018.0192 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Minireview
Kim, Do-Hyoung
Han, Kyou-Hoon
PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title_full PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title_fullStr PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title_full_unstemmed PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title_short PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins
title_sort presmo target-binding signatures in intrinsically disordered proteins
topic Minireview
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199570/
https://www.ncbi.nlm.nih.gov/pubmed/30352491
http://dx.doi.org/10.14348/molcells.2018.0192
work_keys_str_mv AT kimdohyoung presmotargetbindingsignaturesinintrinsicallydisorderedproteins
AT hankyouhoon presmotargetbindingsignaturesinintrinsicallydisorderedproteins