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Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Molecular and Cellular Biology
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199571/ https://www.ncbi.nlm.nih.gov/pubmed/30145862 http://dx.doi.org/10.14348/molcells.2018.0294 |
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author | Sohn, Jee Hyung Kim, Jong In Jeon, Yong Geun Park, Jeu Kim, Jae Bum |
author_facet | Sohn, Jee Hyung Kim, Jong In Jeon, Yong Geun Park, Jeu Kim, Jae Bum |
author_sort | Sohn, Jee Hyung |
collection | PubMed |
description | Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective. |
format | Online Article Text |
id | pubmed-6199571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Korean Society for Molecular and Cellular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-61995712018-11-08 Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis Sohn, Jee Hyung Kim, Jong In Jeon, Yong Geun Park, Jeu Kim, Jae Bum Mol Cells Article Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective. Korean Society for Molecular and Cellular Biology 2018-10-31 2018-10-31 /pmc/articles/PMC6199571/ /pubmed/30145862 http://dx.doi.org/10.14348/molcells.2018.0294 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ |
spellingShingle | Article Sohn, Jee Hyung Kim, Jong In Jeon, Yong Geun Park, Jeu Kim, Jae Bum Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title | Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title_full | Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title_fullStr | Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title_full_unstemmed | Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title_short | Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis |
title_sort | effects of three thiazolidinediones on metabolic regulation and cold-induced thermogenesis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199571/ https://www.ncbi.nlm.nih.gov/pubmed/30145862 http://dx.doi.org/10.14348/molcells.2018.0294 |
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