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Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis

Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs...

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Autores principales: Sohn, Jee Hyung, Kim, Jong In, Jeon, Yong Geun, Park, Jeu, Kim, Jae Bum
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Molecular and Cellular Biology 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199571/
https://www.ncbi.nlm.nih.gov/pubmed/30145862
http://dx.doi.org/10.14348/molcells.2018.0294
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author Sohn, Jee Hyung
Kim, Jong In
Jeon, Yong Geun
Park, Jeu
Kim, Jae Bum
author_facet Sohn, Jee Hyung
Kim, Jong In
Jeon, Yong Geun
Park, Jeu
Kim, Jae Bum
author_sort Sohn, Jee Hyung
collection PubMed
description Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective.
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spelling pubmed-61995712018-11-08 Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis Sohn, Jee Hyung Kim, Jong In Jeon, Yong Geun Park, Jeu Kim, Jae Bum Mol Cells Article Insulin resistance is closely associated with metabolic diseases such as type 2 diabetes, dyslipidemia, hypertension and atherosclerosis. Thiazolidinediones (TZDs) have been developed to ameliorate insulin resistance by activation of peroxisome proliferator-activated receptor (PPAR) γ. Although TZDs are synthetic ligands for PPARγ, metabolic outcomes of each TZD are different. Moreover, there are lack of head-to-head comparative studies among TZDs in the aspect of metabolic outcomes. In this study, we analyzed the effects of three TZDs, including lobeglitazone (Lobe), rosiglitazone (Rosi), and pioglitazone (Pio) on metabolic and thermogenic regulation. In adipocytes, Lobe more potently stimulated adipogenesis and insulin-dependent glucose uptake than Rosi and Pio. In the presence of pro-inflammatory stimuli, Lobe efficiently suppressed expressions of pro-inflammatory genes in macrophages and adipocytes. In obese and diabetic db/db mice, Lobe effectively promoted insulin-stimulated glucose uptake and suppressed pro-inflammatory responses in epididymal white adipose tissue (EAT), leading to improve glucose intolerance. Compared to other two TZDs, Lobe enhanced beige adipocyte formation and thermogenic gene expression in inguinal white adipose tissue (IAT) of lean mice, which would be attributable to cold-induced thermogenesis. Collectively, these comparison data suggest that Lobe could relieve insulin resistance and enhance thermogenesis at low-concentration conditions where Rosi and Pio are less effective. Korean Society for Molecular and Cellular Biology 2018-10-31 2018-10-31 /pmc/articles/PMC6199571/ /pubmed/30145862 http://dx.doi.org/10.14348/molcells.2018.0294 Text en © The Korean Society for Molecular and Cellular Biology. All rights reserved. This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
spellingShingle Article
Sohn, Jee Hyung
Kim, Jong In
Jeon, Yong Geun
Park, Jeu
Kim, Jae Bum
Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title_full Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title_fullStr Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title_full_unstemmed Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title_short Effects of Three Thiazolidinediones on Metabolic Regulation and Cold-Induced Thermogenesis
title_sort effects of three thiazolidinediones on metabolic regulation and cold-induced thermogenesis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199571/
https://www.ncbi.nlm.nih.gov/pubmed/30145862
http://dx.doi.org/10.14348/molcells.2018.0294
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