A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017

BACKGROUND: In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the...

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Autores principales: Wang, Bo, Akanbi, Olusola Anuoluwapo, Harms, Dominik, Adesina, Olufisayo, Osundare, Folakemi Abiodun, Naidoo, Dhamari, Deveaux, Isabel, Ogundiran, Opeayo, Ugochukwu, Uzoma, Mba, Nwando, Ihekweazu, Chikwe, Bock, C.-Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199738/
https://www.ncbi.nlm.nih.gov/pubmed/30352598
http://dx.doi.org/10.1186/s12985-018-1082-8
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author Wang, Bo
Akanbi, Olusola Anuoluwapo
Harms, Dominik
Adesina, Olufisayo
Osundare, Folakemi Abiodun
Naidoo, Dhamari
Deveaux, Isabel
Ogundiran, Opeayo
Ugochukwu, Uzoma
Mba, Nwando
Ihekweazu, Chikwe
Bock, C.-Thomas
author_facet Wang, Bo
Akanbi, Olusola Anuoluwapo
Harms, Dominik
Adesina, Olufisayo
Osundare, Folakemi Abiodun
Naidoo, Dhamari
Deveaux, Isabel
Ogundiran, Opeayo
Ugochukwu, Uzoma
Mba, Nwando
Ihekweazu, Chikwe
Bock, C.-Thomas
author_sort Wang, Bo
collection PubMed
description BACKGROUND: In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. FINDING: The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). CONCLUSIONS: We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation.
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spelling pubmed-61997382018-10-31 A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017 Wang, Bo Akanbi, Olusola Anuoluwapo Harms, Dominik Adesina, Olufisayo Osundare, Folakemi Abiodun Naidoo, Dhamari Deveaux, Isabel Ogundiran, Opeayo Ugochukwu, Uzoma Mba, Nwando Ihekweazu, Chikwe Bock, C.-Thomas Virol J Short Report BACKGROUND: In 2017 the Nigerian Ministry of Health notified the World Health Organization (WHO) of an outbreak of hepatitis E located in the north-east region of the country with 146 cases with 2 deaths. The analysis of the hepatitis E virus (HEV) genotypes responsible for the outbreak revealed the predominance of HEV genotypes 1 (HEV-1) and 2 (HEV-2). Molecular data of HEV-2 genomes are limited; therefore we characterized a HEV-2 strain of the outbreak in more detail. FINDING: The full-length genome sequence of an HEV-2 strain (NG/17–0500) from the outbreak was amplified using newly designed consensus primers. Comparison with other HEV complete genome sequences, including the only HEV-2 strain (Mex-14) with available complete genome sequences and the availability of data of partial HEV-2 sequences from Sub-Saharan Africa, suggests that NG/17–0500 belongs to HEV subtype 2b (HEV-2b). CONCLUSIONS: We identified a novel HEV-2b strain from Sub-Saharan Africa, which is the second complete HEV-2 sequence to date, whose natural history and epidemiology merit further investigation. BioMed Central 2018-10-23 /pmc/articles/PMC6199738/ /pubmed/30352598 http://dx.doi.org/10.1186/s12985-018-1082-8 Text en © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Wang, Bo
Akanbi, Olusola Anuoluwapo
Harms, Dominik
Adesina, Olufisayo
Osundare, Folakemi Abiodun
Naidoo, Dhamari
Deveaux, Isabel
Ogundiran, Opeayo
Ugochukwu, Uzoma
Mba, Nwando
Ihekweazu, Chikwe
Bock, C.-Thomas
A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title_full A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title_fullStr A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title_full_unstemmed A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title_short A new hepatitis E virus genotype 2 strain identified from an outbreak in Nigeria, 2017
title_sort new hepatitis e virus genotype 2 strain identified from an outbreak in nigeria, 2017
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199738/
https://www.ncbi.nlm.nih.gov/pubmed/30352598
http://dx.doi.org/10.1186/s12985-018-1082-8
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