Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes

We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we obse...

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Autores principales: Dudina, Galina A., Donetskova, Almira D., Litvina, Marina M., Mitin, Alexander N., Mitina, Tatiana A., Polyakov, Sergey A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199869/
https://www.ncbi.nlm.nih.gov/pubmed/30405716
http://dx.doi.org/10.1155/2018/8487403
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author Dudina, Galina A.
Donetskova, Almira D.
Litvina, Marina M.
Mitin, Alexander N.
Mitina, Tatiana A.
Polyakov, Sergey A.
author_facet Dudina, Galina A.
Donetskova, Almira D.
Litvina, Marina M.
Mitin, Alexander N.
Mitina, Tatiana A.
Polyakov, Sergey A.
author_sort Dudina, Galina A.
collection PubMed
description We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease.
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spelling pubmed-61998692018-11-07 Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes Dudina, Galina A. Donetskova, Almira D. Litvina, Marina M. Mitin, Alexander N. Mitina, Tatiana A. Polyakov, Sergey A. Adv Hematol Research Article We have investigated the frequencies of regulatory T cells and the level of FOXP3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes and found the significant reduction of regulatory T cells at all stages of the disease. At the same time in untreated patients, we observed the shift in the FOXP3 isoforms expression profile towards the full-length molecule possibly due to inflammation. Based on the already known information about the potentially higher functional activity of FOXP3 molecule lacking exon 2, we have also hypothesized that our finding may explain the high risk of autoimmune disorders in this disease. Hindawi 2018-10-10 /pmc/articles/PMC6199869/ /pubmed/30405716 http://dx.doi.org/10.1155/2018/8487403 Text en Copyright © 2018 Galina A. Dudina et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Dudina, Galina A.
Donetskova, Almira D.
Litvina, Marina M.
Mitin, Alexander N.
Mitina, Tatiana A.
Polyakov, Sergey A.
Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title_full Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title_fullStr Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title_full_unstemmed Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title_short Regulatory T Cells and Profile of FOXP3 Isoforms Expression in Peripheral Blood of Patients with Myelodysplastic Syndromes
title_sort regulatory t cells and profile of foxp3 isoforms expression in peripheral blood of patients with myelodysplastic syndromes
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199869/
https://www.ncbi.nlm.nih.gov/pubmed/30405716
http://dx.doi.org/10.1155/2018/8487403
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