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Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview

There is not a single or combined screening method for preterm birth with high sensitivity which will truly identify the women at risk for preterm birth while also with high specificity to prevent unnecessary interventions and high treatment costs. Measurement of cervical length is the most cost-eff...

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Detalles Bibliográficos
Autores principales: Oskovi Kaplan, Zeynep Asli, Ozgu-Erdinc, A. Seval
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199875/
https://www.ncbi.nlm.nih.gov/pubmed/30405914
http://dx.doi.org/10.1155/2018/8367571
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author Oskovi Kaplan, Zeynep Asli
Ozgu-Erdinc, A. Seval
author_facet Oskovi Kaplan, Zeynep Asli
Ozgu-Erdinc, A. Seval
author_sort Oskovi Kaplan, Zeynep Asli
collection PubMed
description There is not a single or combined screening method for preterm birth with high sensitivity which will truly identify the women at risk for preterm birth while also with high specificity to prevent unnecessary interventions and high treatment costs. Measurement of cervical length is the most cost-effective method that is used in clinical practice. Bedside tests have also been developed for detecting markers like fetal fibronectin, insulin-like growth factor binding protein-1 (IGFBP-1), interleukin-6, and placental alpha-macroglobulin-1. Taking the maternal history, health condition, and sociodemographical factors into consideration is recommended. Ultrasound markers apart from cervical length measurements as uterocervical angle and placental strain ratio are studied. Investigations on metabolomics, proteomics, and microRNA profiling have brought a new aspect on this subject. Maybe in the future, with clear identification of women at true risk for preterm birth, development of more effective preventive strategies will not be unfeasible.
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spelling pubmed-61998752018-11-07 Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview Oskovi Kaplan, Zeynep Asli Ozgu-Erdinc, A. Seval J Pregnancy Review Article There is not a single or combined screening method for preterm birth with high sensitivity which will truly identify the women at risk for preterm birth while also with high specificity to prevent unnecessary interventions and high treatment costs. Measurement of cervical length is the most cost-effective method that is used in clinical practice. Bedside tests have also been developed for detecting markers like fetal fibronectin, insulin-like growth factor binding protein-1 (IGFBP-1), interleukin-6, and placental alpha-macroglobulin-1. Taking the maternal history, health condition, and sociodemographical factors into consideration is recommended. Ultrasound markers apart from cervical length measurements as uterocervical angle and placental strain ratio are studied. Investigations on metabolomics, proteomics, and microRNA profiling have brought a new aspect on this subject. Maybe in the future, with clear identification of women at true risk for preterm birth, development of more effective preventive strategies will not be unfeasible. Hindawi 2018-10-10 /pmc/articles/PMC6199875/ /pubmed/30405914 http://dx.doi.org/10.1155/2018/8367571 Text en Copyright © 2018 Zeynep Asli Oskovi Kaplan and A. Seval Ozgu-Erdinc. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Oskovi Kaplan, Zeynep Asli
Ozgu-Erdinc, A. Seval
Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title_full Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title_fullStr Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title_full_unstemmed Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title_short Prediction of Preterm Birth: Maternal Characteristics, Ultrasound Markers, and Biomarkers: An Updated Overview
title_sort prediction of preterm birth: maternal characteristics, ultrasound markers, and biomarkers: an updated overview
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199875/
https://www.ncbi.nlm.nih.gov/pubmed/30405914
http://dx.doi.org/10.1155/2018/8367571
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