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Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study

Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation...

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Autores principales: Elsner, Viviane Rostirola, Cechinel, Laura Reck, de Meireles, Louisiana Carolina Ferreira, Bertoldi, Karine, Siqueira, Ionara Rodrigues
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199939/
https://www.ncbi.nlm.nih.gov/pubmed/30323148
http://dx.doi.org/10.4103/1673-5374.241467
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author Elsner, Viviane Rostirola
Cechinel, Laura Reck
de Meireles, Louisiana Carolina Ferreira
Bertoldi, Karine
Siqueira, Ionara Rodrigues
author_facet Elsner, Viviane Rostirola
Cechinel, Laura Reck
de Meireles, Louisiana Carolina Ferreira
Bertoldi, Karine
Siqueira, Ionara Rodrigues
author_sort Elsner, Viviane Rostirola
collection PubMed
description Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase (HDAC) activity of adolescent rats at different time points, specifically early morning and afternoon. Both epigenetic markers increased significantly in the hippocampi of female rats compared to the male group, an indicator of reduced transcriptional activity. In addition, HDAC activity during the early morning was higher compared to afternoon groups in both male and female rats, while DNA methyltransferase 1 content was not altered by the time of day. Our findings demonstrate that hippocampal DNA methylation and histone acetylation status can be influenced by gender during the adolescent period, while the time of the day impacts HDAC activity.
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spelling pubmed-61999392018-12-01 Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study Elsner, Viviane Rostirola Cechinel, Laura Reck de Meireles, Louisiana Carolina Ferreira Bertoldi, Karine Siqueira, Ionara Rodrigues Neural Regen Res Research Article Although the involvement of gender in epigenetic machinery in peripheral tissues during the neonatal period has been suggested, the gender-related epigenetic profile of brain areas during the adolescent period is rarely exploited. Furthermore, the influence of time of day on hippocampal acetylation marks has been demonstrated in young adult and aged rats; however, there are no studies reporting epigenetic changes in the adolescent period. Therefore, this study aimed to investigate the effects of gender on hippocampal DNA methyltransferase 1 content and histone deacetylase (HDAC) activity of adolescent rats at different time points, specifically early morning and afternoon. Both epigenetic markers increased significantly in the hippocampi of female rats compared to the male group, an indicator of reduced transcriptional activity. In addition, HDAC activity during the early morning was higher compared to afternoon groups in both male and female rats, while DNA methyltransferase 1 content was not altered by the time of day. Our findings demonstrate that hippocampal DNA methylation and histone acetylation status can be influenced by gender during the adolescent period, while the time of the day impacts HDAC activity. Medknow Publications & Media Pvt Ltd 2018-12 /pmc/articles/PMC6199939/ /pubmed/30323148 http://dx.doi.org/10.4103/1673-5374.241467 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Elsner, Viviane Rostirola
Cechinel, Laura Reck
de Meireles, Louisiana Carolina Ferreira
Bertoldi, Karine
Siqueira, Ionara Rodrigues
Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title_full Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title_fullStr Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title_full_unstemmed Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title_short Epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: A preliminary study
title_sort epigenetic marks are modulated by gender and time of the day in the hippocampi of adolescent rats: a preliminary study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199939/
https://www.ncbi.nlm.nih.gov/pubmed/30323148
http://dx.doi.org/10.4103/1673-5374.241467
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