Cargando…

Inhibiting the kynurenine pathway in spinal cord injury: multiple therapeutic potentials?

Chronic induction of the kynurenine pathway (KP) contributes to neuroinflammation by producing the excitotoxin quinolinic acid (QUIN). This has led to significant interest in the development of inhibitors of this pathway, particularly in the context of neurodegenerative disease. However, acute spina...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jacobs, Kelly R., Lovejoy, David B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Medknow Publications & Media Pvt Ltd 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199950/ https://www.ncbi.nlm.nih.gov/pubmed/30323124 http://dx.doi.org/10.4103/1673-5374.241446

Ejemplares similares

Major Developments in the Design of Inhibitors along the Kynurenine Pathway
por: Jacobs, Kelly R., et al.
Publicado: (2017)

Understanding the role of the kynurenine pathway in human breast cancer immunobiology
por: Heng, Benjamin, et al.
Publicado: (2015)

Kynurenines in the Pathogenesis of Multiple Sclerosis: Therapeutic Perspectives
por: Biernacki, Tamás, et al.
Publicado: (2020)

Kynurenine pathway metabolomics predicts and provides mechanistic insight into multiple sclerosis progression
por: Lim, Chai K., et al.
Publicado: (2017)

The Kynurenine Pathway and Kynurenine 3-Monooxygenase Inhibitors
por: Hughes, Tamera D., et al.
Publicado: (2022)

Therapeutic approaches for spinal cord injury
por: Cristante, Alexandre Fogaça, et al.
Publicado: (2012)

IDO/kynurenine pathway in cancer: possible therapeutic approaches
por: Abd El-Fattah, Eslam E.
Publicado: (2022)

Modulation of Enzyme Activity in the Kynurenine Pathway by Kynurenine Monooxygenase Inhibition
por: Phillips, Robert S., et al.
Publicado: (2019)

Role of Matrix Metalloproteinases and Therapeutic Benefits of Their Inhibition in Spinal Cord Injury
por: Zhang, Haoqian, et al.
Publicado: (2011)

Understanding the Roles of the Kynurenine Pathway in Multiple Sclerosis Progression
por: Lim, Chai K., et al.
Publicado: (2010)

microRNAs in Spinal Cord Injury: Potential Roles and Therapeutic Implications
por: Ning, Bin, et al.
Publicado: (2014)

Pathophysiology and Therapeutic Approaches for Spinal Cord Injury
por: Lima, Rui, et al.
Publicado: (2022)

Potential Therapeutic Targets for PPARγ after Spinal Cord Injury
por: McTigue, Dana M.
Publicado: (2008)

PPARs and the Kynurenine Pathway in Melanoma—Potential Biological Interactions
por: Walczak, Katarzyna, et al.
Publicado: (2023)

Kynurenine Pathway Metabolites as Potential Biomarkers in Chronic Pain
por: Auyeung, Andrew, et al.
Publicado: (2023)

The Role of the Kynurenine Signaling Pathway in Different Chronic Pain Conditions and Potential Use of Therapeutic Agents
por: Jovanovic, Filip, et al.
Publicado: (2020)

Therapeutic effect of umbilical cord blood cells on spinal cord injury
por: Zhang, Jun‐Yan, et al.
Publicado: (2023)

Hypoxia and the Kynurenine Pathway: Implications and Therapeutic Prospects in Alzheimer's Disease
por: Adeyemi, Oluyomi Stephen, et al.
Publicado: (2021)

Spinal Cord Injury and Loss of Cortical Inhibition
por: Benedetti, Bruno, et al.
Publicado: (2022)

Editorial: Multiple Implications of the Kynurenine Pathway in Inflammatory Diseases: Diagnostic and Therapeutic Applications
por: Mándi, Yvette, et al.
Publicado: (2022)

Kynurenine pathway in kidney diseases
por: Zakrocka, Izabela, et al.
Publicado: (2021)

Kynurenine Pathway of Tryptophan Metabolism in Neuropsychiatric Disorders: Pathophysiologic and Therapeutic Considerations
por: Muneer, Ather
Publicado: (2020)

Neuroinflammation and the Kynurenine Pathway in CNS Disease: Molecular Mechanisms and Therapeutic Implications
por: Mithaiwala, Mustafa N., et al.
Publicado: (2021)

Examining the properties and therapeutic potential of glial restricted precursors in spinal cord injury
por: Hayakawa, Kazuo, et al.
Publicado: (2016)

Involvement of Kynurenine Pathway in Hepatocellular Carcinoma
por: Krishnamurthy, Shivani, et al.
Publicado: (2021)

Therapeutic Potential of Niche-Specific Mesenchymal Stromal Cells for Spinal Cord Injury Repair
por: Lindsay, Susan L., et al.
Publicado: (2021)

Ferroptosis: a critical player and potential therapeutic target in traumatic brain injury and spinal cord injury
por: Li, Qing-Sheng, et al.
Publicado: (2022)

MicroRNAs as potential therapeutics for treating spinal cord injury
por: Yan, Hualin, et al.
Publicado: (2012)

Biological Functions and Therapeutic Potential of Autophagy in Spinal Cord Injury
por: Liao, Hai-Yang, et al.
Publicado: (2021)

The kynurenine pathway in traumatic brain injuries and concussion
por: Dehhaghi, Mona, et al.
Publicado: (2023)

New Prophylactic and Therapeutic Strategies for Spinal Cord Injury
por: Park, Sookyoung, et al.
Publicado: (2013)

Spinal cord injury: molecular mechanisms and therapeutic interventions
por: Hu, Xiao, et al.
Publicado: (2023)

Therapeutic Potential of Olfactory Ensheathing Cells and Mesenchymal Stem Cells in Spinal Cord Injuries
por: Anna, Zadroga, et al.
Publicado: (2017)

Sirtuins: Potential Therapeutic Targets for Defense against Oxidative Stress in Spinal Cord Injury
por: Lin, Jialiang, et al.
Publicado: (2021)

The Potential of Curcumin in Treatment of Spinal Cord Injury
por: Sanivarapu, Raghavendra, et al.
Publicado: (2016)

Lentiviral Vectors Delivered with Biomaterials as Therapeutics for Spinal Cord Injury
por: Shortiss, Ciara, et al.
Publicado: (2021)

Therapeutic Strategies for Spinal Cord Injury
por: Jendelova, Pavla
Publicado: (2018)

The Kynurenine Pathway in Stem Cell Biology
por: Jones, Simon P., et al.
Publicado: (2013)

The Footprint of Kynurenine Pathway in Cardiovascular Diseases
por: Ala, Moein, et al.
Publicado: (2022)

A Potential Interface between the Kynurenine Pathway and Autonomic Imbalance in Schizophrenia
por: Büki, Alexandra, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_7kmp9qjmhpgldorrkcqqc60egg