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MicroRNAs of microglia: wrestling with central nervous system disease
Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most imp...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199952/ https://www.ncbi.nlm.nih.gov/pubmed/30323123 http://dx.doi.org/10.4103/1673-5374.241444 |
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author | Wang, Xiao-Hua Wang, Tian-Long |
author_facet | Wang, Xiao-Hua Wang, Tian-Long |
author_sort | Wang, Xiao-Hua |
collection | PubMed |
description | Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroinflammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against central nervous system disease via multiple functional microRNAs. |
format | Online Article Text |
id | pubmed-6199952 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-61999522018-12-01 MicroRNAs of microglia: wrestling with central nervous system disease Wang, Xiao-Hua Wang, Tian-Long Neural Regen Res Review Microglia serve as brain-resident myeloid cells that affect cerebral development, ischemia, neurodegeneration, and neuro-viral infection. MicroRNAs play a key role in central nervous system disease through post-transcriptional regulation. Indeed, evidence shows that microRNAs are one of the most important regulators mediating microglial activation, polarization, and autophagy, and subsequently affecting neuroinflammation and the outcome of central nervous system disease. In this review, we provide insight into the function of microRNAs, which may be an attractive strategy and influential treatment for microglia-related central nervous system dysfunction. Moreover, we comprehensively describe how microglia fight against central nervous system disease via multiple functional microRNAs. Medknow Publications & Media Pvt Ltd 2018-12 /pmc/articles/PMC6199952/ /pubmed/30323123 http://dx.doi.org/10.4103/1673-5374.241444 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Wang, Xiao-Hua Wang, Tian-Long MicroRNAs of microglia: wrestling with central nervous system disease |
title | MicroRNAs of microglia: wrestling with central nervous system disease |
title_full | MicroRNAs of microglia: wrestling with central nervous system disease |
title_fullStr | MicroRNAs of microglia: wrestling with central nervous system disease |
title_full_unstemmed | MicroRNAs of microglia: wrestling with central nervous system disease |
title_short | MicroRNAs of microglia: wrestling with central nervous system disease |
title_sort | micrornas of microglia: wrestling with central nervous system disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199952/ https://www.ncbi.nlm.nih.gov/pubmed/30323123 http://dx.doi.org/10.4103/1673-5374.241444 |
work_keys_str_mv | AT wangxiaohua micrornasofmicrogliawrestlingwithcentralnervoussystemdisease AT wangtianlong micrornasofmicrogliawrestlingwithcentralnervoussystemdisease |