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Prevalence of white matter hyperintensities increases with age

White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the re...

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Autores principales: Zhuang, Feng-Juan, Chen, Yan, He, Wen-Bo, Cai, Zhi-You
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199954/
https://www.ncbi.nlm.nih.gov/pubmed/30323144
http://dx.doi.org/10.4103/1673-5374.241465
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author Zhuang, Feng-Juan
Chen, Yan
He, Wen-Bo
Cai, Zhi-You
author_facet Zhuang, Feng-Juan
Chen, Yan
He, Wen-Bo
Cai, Zhi-You
author_sort Zhuang, Feng-Juan
collection PubMed
description White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis. According to T2-weighted magnetic resonance imaging results, all patients were divided into a WMHs group (n = 333) and a non-WMHs group (n = 503). The WMHs group contained 159 males and 174 females. The prevalence of WMHs increased with age and was associated with age-related risk factors, such as cardiovascular diseases, smoking, drinking, diabetes, hypertension and history of cerebral infarction. There was no significant difference in sex, education level, hyperlipidemia and hyperhomocysteinemia among the different age ranges. These findings confirm that age is an independent risk factor for the prevalence and severity of WMHs. The age-related risk factors enhance the occurrence of WMHs.
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spelling pubmed-61999542018-12-01 Prevalence of white matter hyperintensities increases with age Zhuang, Feng-Juan Chen, Yan He, Wen-Bo Cai, Zhi-You Neural Regen Res Research Article White matter hyperintensities (WMHs) that arise with age and/or atherosclerosis constitute a heterogeneous disorder in the white matter of the brain. However, the relationship between age-related risk factors and the prevalence of WMHs is still obscure. More clinical data is needed to confirm the relationship between age and the prevalence of WMHs. We collected 836 patients, who were treated in the Renmin Hospital, Hubei University of Medicine, China from January 2015 to February 2016, for a case-controlled retrospective analysis. According to T2-weighted magnetic resonance imaging results, all patients were divided into a WMHs group (n = 333) and a non-WMHs group (n = 503). The WMHs group contained 159 males and 174 females. The prevalence of WMHs increased with age and was associated with age-related risk factors, such as cardiovascular diseases, smoking, drinking, diabetes, hypertension and history of cerebral infarction. There was no significant difference in sex, education level, hyperlipidemia and hyperhomocysteinemia among the different age ranges. These findings confirm that age is an independent risk factor for the prevalence and severity of WMHs. The age-related risk factors enhance the occurrence of WMHs. Medknow Publications & Media Pvt Ltd 2018-12 /pmc/articles/PMC6199954/ /pubmed/30323144 http://dx.doi.org/10.4103/1673-5374.241465 Text en Copyright: © Neural Regeneration Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Research Article
Zhuang, Feng-Juan
Chen, Yan
He, Wen-Bo
Cai, Zhi-You
Prevalence of white matter hyperintensities increases with age
title Prevalence of white matter hyperintensities increases with age
title_full Prevalence of white matter hyperintensities increases with age
title_fullStr Prevalence of white matter hyperintensities increases with age
title_full_unstemmed Prevalence of white matter hyperintensities increases with age
title_short Prevalence of white matter hyperintensities increases with age
title_sort prevalence of white matter hyperintensities increases with age
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199954/
https://www.ncbi.nlm.nih.gov/pubmed/30323144
http://dx.doi.org/10.4103/1673-5374.241465
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