No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti

We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti....

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Autores principales: Vincent, Jeanne P., Komaki-Yasuda, Kanako, Existe, Alexandre V., Boncy, Jacques, Kano, Shigeyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2018
Materias:
Research Letter
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199976/
https://www.ncbi.nlm.nih.gov/pubmed/30334724
http://dx.doi.org/10.3201/eid2411.180738
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author Vincent, Jeanne P.
Komaki-Yasuda, Kanako
Existe, Alexandre V.
Boncy, Jacques
Kano, Shigeyuki
author_facet Vincent, Jeanne P.
Komaki-Yasuda, Kanako
Existe, Alexandre V.
Boncy, Jacques
Kano, Shigeyuki
author_sort Vincent, Jeanne P.
collection PubMed
description We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti. Artemisinin-based therapy can be used as alternative therapy.
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spelling pubmed-61999762018-11-08 No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti Vincent, Jeanne P. Komaki-Yasuda, Kanako Existe, Alexandre V. Boncy, Jacques Kano, Shigeyuki Emerg Infect Dis Research Letter We obtained 78 human blood samples from areas in Haiti with high transmission of malaria and found no drug resistance–associated mutations in Plasmodium falciparum chloroquine resistance transporter and Kelch 13 genes. We recommend maintaining chloroquine as the first-line drug for malaria in Haiti. Artemisinin-based therapy can be used as alternative therapy. Centers for Disease Control and Prevention 2018-11 /pmc/articles/PMC6199976/ /pubmed/30334724 http://dx.doi.org/10.3201/eid2411.180738 Text en https://creativecommons.org/licenses/by/4.0/This is a publication of the U.S. Government. This publication is in the public domain and is therefore without copyright. All text from this work may be reprinted freely. Use of these materials should be properly cited.
spellingShingle Research Letter
Vincent, Jeanne P.
Komaki-Yasuda, Kanako
Existe, Alexandre V.
Boncy, Jacques
Kano, Shigeyuki
No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title_full No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title_fullStr No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title_full_unstemmed No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title_short No Plasmodium falciparum Chloroquine Resistance Transporter and Artemisinin Resistance Mutations, Haiti
title_sort no plasmodium falciparum chloroquine resistance transporter and artemisinin resistance mutations, haiti
topic Research Letter
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6199976/
https://www.ncbi.nlm.nih.gov/pubmed/30334724
http://dx.doi.org/10.3201/eid2411.180738
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