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Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly

Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Protein nutrition has been shown to stimulate and strengthen the immune system, and such approaches are needed for this growing segment of the population. A controlled, randomized, double blind p...

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Autores principales: Schaefer, Sara, Hettinga, Kasper Arthur, Cullor, James, German, J. Bruce, Henrick, Bethany M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200024/
https://www.ncbi.nlm.nih.gov/pubmed/30386327
http://dx.doi.org/10.3389/fimmu.2018.02254
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author Schaefer, Sara
Hettinga, Kasper Arthur
Cullor, James
German, J. Bruce
Henrick, Bethany M.
author_facet Schaefer, Sara
Hettinga, Kasper Arthur
Cullor, James
German, J. Bruce
Henrick, Bethany M.
author_sort Schaefer, Sara
collection PubMed
description Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Protein nutrition has been shown to stimulate and strengthen the immune system, and such approaches are needed for this growing segment of the population. A controlled, randomized, double blind pilot study was conducted to compare two different protein sources (soy and dairy) as nutritional supplementation to enhance vaccine response. Our objective was to examine the immune stimulating effects of dairy protein subjected to ultraviolet radiation (UV-C) radiation treatment process instead of pasteurization. Participants were 21 healthy individuals over 60 years of age who consumed 6 g of the dairy protein or a comparison, soy isoflavone protein, twice a day for 8 weeks. DTaP vaccine administered at week 4. Non-parametric t-tests revealed a significant increase in Tetanus antibodies in the dairy group compared to the soy group at week 8. These findings suggest additional benefits of UV-C treated unheated dairy protein as a solution to counteract immunosenescence, but warrant further study in elderly and other populations that might benefit from immune system stimulation.
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spelling pubmed-62000242018-11-01 Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly Schaefer, Sara Hettinga, Kasper Arthur Cullor, James German, J. Bruce Henrick, Bethany M. Front Immunol Immunology Aging populations experience a decline in adaptive immune system function also known as immunosenesence. Protein nutrition has been shown to stimulate and strengthen the immune system, and such approaches are needed for this growing segment of the population. A controlled, randomized, double blind pilot study was conducted to compare two different protein sources (soy and dairy) as nutritional supplementation to enhance vaccine response. Our objective was to examine the immune stimulating effects of dairy protein subjected to ultraviolet radiation (UV-C) radiation treatment process instead of pasteurization. Participants were 21 healthy individuals over 60 years of age who consumed 6 g of the dairy protein or a comparison, soy isoflavone protein, twice a day for 8 weeks. DTaP vaccine administered at week 4. Non-parametric t-tests revealed a significant increase in Tetanus antibodies in the dairy group compared to the soy group at week 8. These findings suggest additional benefits of UV-C treated unheated dairy protein as a solution to counteract immunosenescence, but warrant further study in elderly and other populations that might benefit from immune system stimulation. Frontiers Media S.A. 2018-10-17 /pmc/articles/PMC6200024/ /pubmed/30386327 http://dx.doi.org/10.3389/fimmu.2018.02254 Text en Copyright © 2018 Schaefer, Hettinga, Cullor, German and Henrick. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Schaefer, Sara
Hettinga, Kasper Arthur
Cullor, James
German, J. Bruce
Henrick, Bethany M.
Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title_full Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title_fullStr Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title_full_unstemmed Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title_short Use of UV Treated Milk Powder to Increase Vaccine Efficacy in the Elderly
title_sort use of uv treated milk powder to increase vaccine efficacy in the elderly
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200024/
https://www.ncbi.nlm.nih.gov/pubmed/30386327
http://dx.doi.org/10.3389/fimmu.2018.02254
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