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Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies
BACKGROUND: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies. METHODS: Between 2001 and 2017, 21 patients with pulmonar...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Korean Society for Thoracic and Cardiovascular Surgery
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200165/ https://www.ncbi.nlm.nih.gov/pubmed/30402396 http://dx.doi.org/10.5090/kjtcs.2018.51.5.350 |
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author | Yamamichi, Takashi Horio, Hirotoshi Asakawa, Ayaka Okui, Masayuki Harada, Masahiko |
author_facet | Yamamichi, Takashi Horio, Hirotoshi Asakawa, Ayaka Okui, Masayuki Harada, Masahiko |
author_sort | Yamamichi, Takashi |
collection | PubMed |
description | BACKGROUND: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies. METHODS: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. RESULTS: The median age of the patients was 47 years, and 13 were male. The histological diagnoses were pulmonary aspergillosis (19 cases), mucormycosis (1 case), and cryptococcosis (1 case). The indications for surgery were resistance to antifungal therapy and the necessity of surgery before hematopoietic stem cell transplantation in 13 and 8 cases, respectively. The diagnoses of the hematological malignancies were acute myelogenous leukemia (10 cases), acute lymphocytic leukemia (5 cases), myelodysplastic syndrome (3 cases), and chronic myelogenous leukemia, malignant lymphoma, and extramedullary plasmacytoma (1 case each). The surgical procedures were partial resection (11 cases), segmentectomy (5 cases), lobectomy (4 cases), and cavernostomy (1 case). The size of the lesions was 0.9–8.5 cm. Fourteen cases had cavitation. There were no surgical-related deaths or fungal progression. CONCLUSION: Pulmonary fungal infections are resistant to treatments for hematological malignancies. Since the treatment of the underlying disease is extended and these infections often recur and are exacerbated, surgery should be considered when possible. |
format | Online Article Text |
id | pubmed-6200165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Society for Thoracic and Cardiovascular Surgery |
record_format | MEDLINE/PubMed |
spelling | pubmed-62001652018-11-06 Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies Yamamichi, Takashi Horio, Hirotoshi Asakawa, Ayaka Okui, Masayuki Harada, Masahiko Korean J Thorac Cardiovasc Surg Key References BACKGROUND: The complication rate of fungal disease is higher among patients with hematological malignancies. We investigated the clinicobacteriological outcomes of resected pulmonary fungal infections complicating hematological malignancies. METHODS: Between 2001 and 2017, 21 patients with pulmonary fungal infections complicating hematological malignancies underwent resection, and their clinical records and survival were retrospectively reviewed. RESULTS: The median age of the patients was 47 years, and 13 were male. The histological diagnoses were pulmonary aspergillosis (19 cases), mucormycosis (1 case), and cryptococcosis (1 case). The indications for surgery were resistance to antifungal therapy and the necessity of surgery before hematopoietic stem cell transplantation in 13 and 8 cases, respectively. The diagnoses of the hematological malignancies were acute myelogenous leukemia (10 cases), acute lymphocytic leukemia (5 cases), myelodysplastic syndrome (3 cases), and chronic myelogenous leukemia, malignant lymphoma, and extramedullary plasmacytoma (1 case each). The surgical procedures were partial resection (11 cases), segmentectomy (5 cases), lobectomy (4 cases), and cavernostomy (1 case). The size of the lesions was 0.9–8.5 cm. Fourteen cases had cavitation. There were no surgical-related deaths or fungal progression. CONCLUSION: Pulmonary fungal infections are resistant to treatments for hematological malignancies. Since the treatment of the underlying disease is extended and these infections often recur and are exacerbated, surgery should be considered when possible. The Korean Society for Thoracic and Cardiovascular Surgery 2018-10 2018-10-05 /pmc/articles/PMC6200165/ /pubmed/30402396 http://dx.doi.org/10.5090/kjtcs.2018.51.5.350 Text en Copyright © 2018 by The Korean Society for Thoracic and Cardiovascular Surgery. All rights Reserved. This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Key References Yamamichi, Takashi Horio, Hirotoshi Asakawa, Ayaka Okui, Masayuki Harada, Masahiko Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title | Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title_full | Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title_fullStr | Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title_full_unstemmed | Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title_short | Surgery for Pulmonary Fungal Infections Complicating Hematological Malignancies |
title_sort | surgery for pulmonary fungal infections complicating hematological malignancies |
topic | Key References |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200165/ https://www.ncbi.nlm.nih.gov/pubmed/30402396 http://dx.doi.org/10.5090/kjtcs.2018.51.5.350 |
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