Single copy/knock-in models of ALS SOD1 in C. elegans suggest loss and gain of function have different contributions to cholinergic and glutamatergic neurodegeneration

Mutations in Cu/Zn superoxide dismutase 1 (SOD1) lead to Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that disproportionately affects glutamatergic and cholinergic motor neurons. Previous work with SOD1 overexpression models supports a role for SOD1 toxic gain of function in ALS...

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Detalles Bibliográficos
Autores principales: Baskoylu, Saba N., Yersak, Jill, O’Hern, Patrick, Grosser, Sarah, Simon, Jonah, Kim, Sarah, Schuch, Kelsey, Dimitriadi, Maria, Yanagi, Katherine S., Lins, Jeremy, Hart, Anne C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200258/
https://www.ncbi.nlm.nih.gov/pubmed/30296255
http://dx.doi.org/10.1371/journal.pgen.1007682

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