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Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows
INTRODUCTION: Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS). MATERIAL AND METHODS: A to...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sciendo
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200290/ https://www.ncbi.nlm.nih.gov/pubmed/30364907 http://dx.doi.org/10.2478/jvetres-2018-0029 |
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author | Rodriguez, Alfredo Rosamel Herzberg, Daniel Eduardo Werner, Marianne Patricia Müller, Heine Yacob Bustamante, Hedie Almagro |
author_facet | Rodriguez, Alfredo Rosamel Herzberg, Daniel Eduardo Werner, Marianne Patricia Müller, Heine Yacob Bustamante, Hedie Almagro |
author_sort | Rodriguez, Alfredo Rosamel |
collection | PubMed |
description | INTRODUCTION: Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS). MATERIAL AND METHODS: A total of 100 Friesian and Jersey cows with lameness (parity range: 1–6; weight: 400–500 kg; milk yield: 22–28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0–3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA. RESULTS: Cows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows. CONCLUSION: Variations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions. |
format | Online Article Text |
id | pubmed-6200290 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Sciendo |
record_format | MEDLINE/PubMed |
spelling | pubmed-62002902018-10-25 Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows Rodriguez, Alfredo Rosamel Herzberg, Daniel Eduardo Werner, Marianne Patricia Müller, Heine Yacob Bustamante, Hedie Almagro J Vet Res Research Article INTRODUCTION: Lameness is a painful and debilitating condition that affects dairy cows worldwide. The aim of this study was to determine the plasma concentration of norepinephrine, β-endorphin, and substance P in dairy cows with lameness and different mobility scores (MS). MATERIAL AND METHODS: A total of 100 Friesian and Jersey cows with lameness (parity range: 1–6; weight: 400–500 kg; milk yield: 22–28 L a day, and lactation stage less than 230 days) were selected. Animals were selected and grouped according to MS (MS 0–3; n = 25), and plasma concentration of norepinephrine, substance P, and β-endorphin was measured using ELISA. RESULTS: Cows with MS 3 had higher plasma concentrations of norepinephrine and substance P and lower plasma concentrations of β-endorphins when compared to MS 0 cows. CONCLUSION: Variations in plasma concentration of norepinephrine, substance P, and β-endorphin could be associated with intense pain states in dairy cows with lameness, but are insufficient to differentiate these states from the mildest pain states. Further studies are necessary in order to evaluate the potential use of these biomarkers in the detection of chronic bovine painful conditions. Sciendo 2018-10-24 /pmc/articles/PMC6200290/ /pubmed/30364907 http://dx.doi.org/10.2478/jvetres-2018-0029 Text en © 2018 Alfredo Rosamel Rodriguez et al., published by Sciendo http://creativecommons.org/licenses/by-nc-nd/3.0 This work is licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 3.0 License. |
spellingShingle | Research Article Rodriguez, Alfredo Rosamel Herzberg, Daniel Eduardo Werner, Marianne Patricia Müller, Heine Yacob Bustamante, Hedie Almagro Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title | Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title_full | Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title_fullStr | Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title_full_unstemmed | Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title_short | Plasma Concentration of Norepinephrine, β-endorphin, and Substance P in Lame Dairy Cows |
title_sort | plasma concentration of norepinephrine, β-endorphin, and substance p in lame dairy cows |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200290/ https://www.ncbi.nlm.nih.gov/pubmed/30364907 http://dx.doi.org/10.2478/jvetres-2018-0029 |
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