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Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?

In advanced Duchenne muscular dystrophy (DMD), patients with high bone fracture risk due to osteoporosis, it is difficult to measure spinal bone mineral density (BMD) because of maintaining proper posture. This study began with the idea that if we diagnose and manage osteoporosis by predicting spina...

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Autores principales: Kim, Eunyoung, Cho, Han Eol, Jung, Ji Ho, Lee, Jang Woo, Choi, Won Ah, Kang, Seong-Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200494/
https://www.ncbi.nlm.nih.gov/pubmed/30290594
http://dx.doi.org/10.1097/MD.0000000000012303
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author Kim, Eunyoung
Cho, Han Eol
Jung, Ji Ho
Lee, Jang Woo
Choi, Won Ah
Kang, Seong-Woong
author_facet Kim, Eunyoung
Cho, Han Eol
Jung, Ji Ho
Lee, Jang Woo
Choi, Won Ah
Kang, Seong-Woong
author_sort Kim, Eunyoung
collection PubMed
description In advanced Duchenne muscular dystrophy (DMD), patients with high bone fracture risk due to osteoporosis, it is difficult to measure spinal bone mineral density (BMD) because of maintaining proper posture. This study began with the idea that if we diagnose and manage osteoporosis by predicting spinal BMD through easily testable radial BMD, we could prevent fracture and improve quality of life in DMD patients. In 61 DMD patients aged 20 years or older who were admitted to Gangnam Severance Hospital from April 2013 to May 2015, radial BMD and spinal BMD were measured to compare their Z-scores. In 45 patients, the z-score was less than −2.0 in spinal BMD defined as osteoporosis. And the optimal range of Z-score in the radius was −5.2 to −5.0 (sensitivity 78.9%, specificity 71.4%). Only through the radius BMD, spinal BMD can be predicted and we suggest appropriate times for treatments.
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spelling pubmed-62004942018-11-07 Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy? Kim, Eunyoung Cho, Han Eol Jung, Ji Ho Lee, Jang Woo Choi, Won Ah Kang, Seong-Woong Medicine (Baltimore) Research Article In advanced Duchenne muscular dystrophy (DMD), patients with high bone fracture risk due to osteoporosis, it is difficult to measure spinal bone mineral density (BMD) because of maintaining proper posture. This study began with the idea that if we diagnose and manage osteoporosis by predicting spinal BMD through easily testable radial BMD, we could prevent fracture and improve quality of life in DMD patients. In 61 DMD patients aged 20 years or older who were admitted to Gangnam Severance Hospital from April 2013 to May 2015, radial BMD and spinal BMD were measured to compare their Z-scores. In 45 patients, the z-score was less than −2.0 in spinal BMD defined as osteoporosis. And the optimal range of Z-score in the radius was −5.2 to −5.0 (sensitivity 78.9%, specificity 71.4%). Only through the radius BMD, spinal BMD can be predicted and we suggest appropriate times for treatments. Wolters Kluwer Health 2018-10-05 /pmc/articles/PMC6200494/ /pubmed/30290594 http://dx.doi.org/10.1097/MD.0000000000012303 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Kim, Eunyoung
Cho, Han Eol
Jung, Ji Ho
Lee, Jang Woo
Choi, Won Ah
Kang, Seong-Woong
Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title_full Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title_fullStr Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title_full_unstemmed Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title_short Can radial bone mineral density predict spinal bone mineral density in patients with advanced Duchenne muscular dystrophy?
title_sort can radial bone mineral density predict spinal bone mineral density in patients with advanced duchenne muscular dystrophy?
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200494/
https://www.ncbi.nlm.nih.gov/pubmed/30290594
http://dx.doi.org/10.1097/MD.0000000000012303
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