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(99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma

This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of (99m)Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparath...

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Autores principales: Chen, Zejun, Fu, Jingjing, Shao, Qing, Zhou, Bin, Wang, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200521/
https://www.ncbi.nlm.nih.gov/pubmed/30290620
http://dx.doi.org/10.1097/MD.0000000000012578
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author Chen, Zejun
Fu, Jingjing
Shao, Qing
Zhou, Bin
Wang, Feng
author_facet Chen, Zejun
Fu, Jingjing
Shao, Qing
Zhou, Bin
Wang, Feng
author_sort Chen, Zejun
collection PubMed
description This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of (99m)Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent (99m)Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. All primary and recurrent lesions showed high focal uptake on (99m)Tc-MIBI image, whereas metastatic lymph nodes gave false negative results. The serum PTH was 165.14 ± 90.26 pmol/L, which declined rapidly after surgery. One patient with a persistently high PTH (147.5 pmol/L) after surgery presented with multiple lymphadenopathy in the neck. Higher expression of chromogranin A (CgA) further confirmed parathyroid carcinoma as a rare endocrine tumor. Parathyroid carcinoma is thus usually diagnosed incidentally based on nonspecific multiorgan symptoms of hypercalcemia and hyperparathyroidism. (99m)Tc-MIBI SPECT/CT may help to localize the parathyroid carcinoma, while MRI is valuable for detecting metastasis. Serum PTH and CgA serve as circulating biomarkers in parathyroid carcinoma, and raised levels of PTH and CgA together with locoregional lymphadenopathy may indicate parathyroid carcinoma. Further studies are needed.
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spelling pubmed-62005212018-11-07 (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma Chen, Zejun Fu, Jingjing Shao, Qing Zhou, Bin Wang, Feng Medicine (Baltimore) Research Article This study aimed to evaluate the characteristics of parathyroid carcinoma and to validate the diagnostic value of (99m)Tc-methoxyisobutylisonitrile (MIBI) single photon emission computed tomography/x-ray computed tomography (SPECT/CT) for differentiating between parathyroid carcinoma and hyperparathyroidism. Four consecutive patients with suspected primary hyperparathyroidism were enrolled in this study and underwent (99m)Tc-MIBI SPECT/CT, ultrasonography, enhanced CT, and MRI. Serum parathyroid hormone (PTH) and calcium were measured. All primary and recurrent lesions showed high focal uptake on (99m)Tc-MIBI image, whereas metastatic lymph nodes gave false negative results. The serum PTH was 165.14 ± 90.26 pmol/L, which declined rapidly after surgery. One patient with a persistently high PTH (147.5 pmol/L) after surgery presented with multiple lymphadenopathy in the neck. Higher expression of chromogranin A (CgA) further confirmed parathyroid carcinoma as a rare endocrine tumor. Parathyroid carcinoma is thus usually diagnosed incidentally based on nonspecific multiorgan symptoms of hypercalcemia and hyperparathyroidism. (99m)Tc-MIBI SPECT/CT may help to localize the parathyroid carcinoma, while MRI is valuable for detecting metastasis. Serum PTH and CgA serve as circulating biomarkers in parathyroid carcinoma, and raised levels of PTH and CgA together with locoregional lymphadenopathy may indicate parathyroid carcinoma. Further studies are needed. Wolters Kluwer Health 2018-10-05 /pmc/articles/PMC6200521/ /pubmed/30290620 http://dx.doi.org/10.1097/MD.0000000000012578 Text en Copyright © 2018 the Author(s). Published by Wolters Kluwer Health, Inc. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle Research Article
Chen, Zejun
Fu, Jingjing
Shao, Qing
Zhou, Bin
Wang, Feng
(99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title_full (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title_fullStr (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title_full_unstemmed (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title_short (99m)Tc-MIBI single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
title_sort (99m)tc-mibi single photon emission computed tomography/computed tomography for the incidental detection of rare parathyroid carcinoma
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200521/
https://www.ncbi.nlm.nih.gov/pubmed/30290620
http://dx.doi.org/10.1097/MD.0000000000012578
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