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Parasites as negative regulators of cancer

Several environmental factors (chemical, physical, and biological) can cause the initiation, promotion, and progression of cancer. Regarding the biological factors, several studies have found that infections caused by some bacteria, viruses and protozoan, and helminth parasites are related to carcin...

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Autores principales: Callejas, Blanca E., Martínez-Saucedo, Diana, Terrazas, Luis I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200699/
https://www.ncbi.nlm.nih.gov/pubmed/30266743
http://dx.doi.org/10.1042/BSR20180935
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author Callejas, Blanca E.
Martínez-Saucedo, Diana
Terrazas, Luis I.
author_facet Callejas, Blanca E.
Martínez-Saucedo, Diana
Terrazas, Luis I.
author_sort Callejas, Blanca E.
collection PubMed
description Several environmental factors (chemical, physical, and biological) can cause the initiation, promotion, and progression of cancer. Regarding the biological factors, several studies have found that infections caused by some bacteria, viruses and protozoan, and helminth parasites are related to carcinogenesis. However, in recent years a different approach has been implemented on the antitumor impact of parasitic diseases caused by some protozoan and helminths, mainly because such infections may affect several hallmarks of cancer, but the involved mechanisms still remain unknown. The beneficial effects reported for some parasitic diseases on tumorigenesis range from the induction of apoptosis, activation of the immune response, avoiding metastasis and angiogenesis, inhibition of proliferative signals, to the regulation of inflammatory responses that promote cancer. In this work, we reviewed the available information regarding how parasitic infections may modulate cancer progression. Despite the fact that specific mechanisms of action on tumors are not yet totally clear, we consider that detailed studies of the antitumor action of these organisms and their products could lead to the discovery and use of new molecules from these biological agents that may work as adjuvant therapy in the treatment of various types of cancer.
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spelling pubmed-62006992018-11-07 Parasites as negative regulators of cancer Callejas, Blanca E. Martínez-Saucedo, Diana Terrazas, Luis I. Biosci Rep Review Articles Several environmental factors (chemical, physical, and biological) can cause the initiation, promotion, and progression of cancer. Regarding the biological factors, several studies have found that infections caused by some bacteria, viruses and protozoan, and helminth parasites are related to carcinogenesis. However, in recent years a different approach has been implemented on the antitumor impact of parasitic diseases caused by some protozoan and helminths, mainly because such infections may affect several hallmarks of cancer, but the involved mechanisms still remain unknown. The beneficial effects reported for some parasitic diseases on tumorigenesis range from the induction of apoptosis, activation of the immune response, avoiding metastasis and angiogenesis, inhibition of proliferative signals, to the regulation of inflammatory responses that promote cancer. In this work, we reviewed the available information regarding how parasitic infections may modulate cancer progression. Despite the fact that specific mechanisms of action on tumors are not yet totally clear, we consider that detailed studies of the antitumor action of these organisms and their products could lead to the discovery and use of new molecules from these biological agents that may work as adjuvant therapy in the treatment of various types of cancer. Portland Press Ltd. 2018-10-23 /pmc/articles/PMC6200699/ /pubmed/30266743 http://dx.doi.org/10.1042/BSR20180935 Text en © 2018 The Author(s). http://creativecommons.org/licenses/by/4.0/This is an open access article published by Portland Press Limited on behalf of the Biochemical Society and distributed under the Creative Commons Attribution License 4.0 (CC BY) (http://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Articles
Callejas, Blanca E.
Martínez-Saucedo, Diana
Terrazas, Luis I.
Parasites as negative regulators of cancer
title Parasites as negative regulators of cancer
title_full Parasites as negative regulators of cancer
title_fullStr Parasites as negative regulators of cancer
title_full_unstemmed Parasites as negative regulators of cancer
title_short Parasites as negative regulators of cancer
title_sort parasites as negative regulators of cancer
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200699/
https://www.ncbi.nlm.nih.gov/pubmed/30266743
http://dx.doi.org/10.1042/BSR20180935
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