Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) preferably locates in the nucleus in HPV16-positive...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Yuan, Guo, Ji-Zheng, Liu, Ying, Wang, Kui, Ding, Wencheng, Wang, Hui, Liu, Xiang, Zhou, Shengtao, Lu, Xiao-Chen, Yang, Hong-Bin, Xu, Chenyue, Gao, Wei, Zhou, Li, Wang, Yi-Ping, Hu, Weiguo, Wei, Yuquan, Huang, Canhua, Lei, Qun-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200739/
https://www.ncbi.nlm.nih.gov/pubmed/30356100
http://dx.doi.org/10.1038/s41467-018-06841-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200739/
https://www.ncbi.nlm.nih.gov/pubmed/30356100
http://dx.doi.org/10.1038/s41467-018-06841-7

Ejemplares similares