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Nuclear lactate dehydrogenase A senses ROS to produce α-hydroxybutyrate for HPV-induced cervical tumor growth

It is well known that high-risk human papilloma virus (HR-HPV) infection is strongly associated with cervical cancer and E7 was identified as one of the key initiators in HPV-mediated carcinogenesis. Here we show that lactate dehydrogenase A (LDHA) preferably locates in the nucleus in HPV16-positive...

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Detalles Bibliográficos
Autores principales:	Liu, Yuan, Guo, Ji-Zheng, Liu, Ying, Wang, Kui, Ding, Wencheng, Wang, Hui, Liu, Xiang, Zhou, Shengtao, Lu, Xiao-Chen, Yang, Hong-Bin, Xu, Chenyue, Gao, Wei, Zhou, Li, Wang, Yi-Ping, Hu, Weiguo, Wei, Yuquan, Huang, Canhua, Lei, Qun-Ying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200739/ https://www.ncbi.nlm.nih.gov/pubmed/30356100 http://dx.doi.org/10.1038/s41467-018-06841-7

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