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Multisensory integration in rodent tactile but not visual thalamus
Behavioural performance requires a coherent perception of environmental features that address multiple senses. These diverse sensory inputs are integrated in primary sensory cortices, yet it is still largely unknown whether their convergence occurs even earlier along the sensory tract. Here we inves...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200796/ https://www.ncbi.nlm.nih.gov/pubmed/30356135 http://dx.doi.org/10.1038/s41598-018-33815-y |
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author | Bieler, Malte Xu, Xiaxia Marquardt, Annette Hanganu-Opatz, Ileana L. |
author_facet | Bieler, Malte Xu, Xiaxia Marquardt, Annette Hanganu-Opatz, Ileana L. |
author_sort | Bieler, Malte |
collection | PubMed |
description | Behavioural performance requires a coherent perception of environmental features that address multiple senses. These diverse sensory inputs are integrated in primary sensory cortices, yet it is still largely unknown whether their convergence occurs even earlier along the sensory tract. Here we investigate the role of putatively modality-specific first-order (FO) thalamic nuclei (ventral posteromedial nucleus (VPM), dorsal lateral geniculate nucleus (dLGN)) and their interactions with primary sensory cortices (S1, V1) for multisensory integration in pigmented rats in vivo. We show that bimodal stimulation (i.e. simultaneous light flash and whisker deflection) enhances sensory evoked activity in VPM, but not dLGN. Moreover, cross-modal stimuli reset the phase of thalamic network oscillations and strengthen the coupling efficiency between VPM and S1, but not between dLGN and V1. Finally, the information flow from VPM to S1 is enhanced. Thus, FO tactile, but not visual, thalamus processes and relays sensory inputs from multiple senses, revealing a functional difference between sensory thalamic nuclei during multisensory integration. |
format | Online Article Text |
id | pubmed-6200796 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-62007962018-10-26 Multisensory integration in rodent tactile but not visual thalamus Bieler, Malte Xu, Xiaxia Marquardt, Annette Hanganu-Opatz, Ileana L. Sci Rep Article Behavioural performance requires a coherent perception of environmental features that address multiple senses. These diverse sensory inputs are integrated in primary sensory cortices, yet it is still largely unknown whether their convergence occurs even earlier along the sensory tract. Here we investigate the role of putatively modality-specific first-order (FO) thalamic nuclei (ventral posteromedial nucleus (VPM), dorsal lateral geniculate nucleus (dLGN)) and their interactions with primary sensory cortices (S1, V1) for multisensory integration in pigmented rats in vivo. We show that bimodal stimulation (i.e. simultaneous light flash and whisker deflection) enhances sensory evoked activity in VPM, but not dLGN. Moreover, cross-modal stimuli reset the phase of thalamic network oscillations and strengthen the coupling efficiency between VPM and S1, but not between dLGN and V1. Finally, the information flow from VPM to S1 is enhanced. Thus, FO tactile, but not visual, thalamus processes and relays sensory inputs from multiple senses, revealing a functional difference between sensory thalamic nuclei during multisensory integration. Nature Publishing Group UK 2018-10-24 /pmc/articles/PMC6200796/ /pubmed/30356135 http://dx.doi.org/10.1038/s41598-018-33815-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Bieler, Malte Xu, Xiaxia Marquardt, Annette Hanganu-Opatz, Ileana L. Multisensory integration in rodent tactile but not visual thalamus |
title | Multisensory integration in rodent tactile but not visual thalamus |
title_full | Multisensory integration in rodent tactile but not visual thalamus |
title_fullStr | Multisensory integration in rodent tactile but not visual thalamus |
title_full_unstemmed | Multisensory integration in rodent tactile but not visual thalamus |
title_short | Multisensory integration in rodent tactile but not visual thalamus |
title_sort | multisensory integration in rodent tactile but not visual thalamus |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200796/ https://www.ncbi.nlm.nih.gov/pubmed/30356135 http://dx.doi.org/10.1038/s41598-018-33815-y |
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