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Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI

Cognitive decline is often undetectable in the early stages of accelerated vascular aging. Attentional processes are particularly affected in older adults with white matter hyperintensities (WMH), although specific neurovascular mechanisms have not been elucidated. We aimed to identify differences i...

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Autores principales: Atwi, Sarah, Metcalfe, Arron W. S., Robertson, Andrew D., Rezmovitz, Jeremy, Anderson, Nicole D., MacIntosh, Bradley J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200839/
https://www.ncbi.nlm.nih.gov/pubmed/30405336
http://dx.doi.org/10.3389/fnins.2018.00748
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author Atwi, Sarah
Metcalfe, Arron W. S.
Robertson, Andrew D.
Rezmovitz, Jeremy
Anderson, Nicole D.
MacIntosh, Bradley J.
author_facet Atwi, Sarah
Metcalfe, Arron W. S.
Robertson, Andrew D.
Rezmovitz, Jeremy
Anderson, Nicole D.
MacIntosh, Bradley J.
author_sort Atwi, Sarah
collection PubMed
description Cognitive decline is often undetectable in the early stages of accelerated vascular aging. Attentional processes are particularly affected in older adults with white matter hyperintensities (WMH), although specific neurovascular mechanisms have not been elucidated. We aimed to identify differences in attention-related neurofunctional activation and behavior between adults with and without WMH. Older adults with moderate to severe WMH (n = 18, mean age = 70 years), age-matched adults (n = 28, mean age = 72), and healthy younger adults (n = 19, mean age = 25) performed a modified flanker task during multi-echo blood oxygenation level dependent functional magnetic resonance imaging. Task-related activation was assessed using a weighted-echo approach. Healthy older adults had more widespread response and higher amplitude of activation compared to WMH adults in fronto-temporal and parietal cortices. Activation associated with processing speed was absent in the WMH group, suggesting attention-related activation deficits that may be a consequence of cerebral small vessel disease. WMH adults had greater executive contrast activation in the precuneous and posterior cingulate gyrus compared to HYA, despite no performance benefits, reinforcing the network dysfunction theory in WMH.
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spelling pubmed-62008392018-11-07 Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI Atwi, Sarah Metcalfe, Arron W. S. Robertson, Andrew D. Rezmovitz, Jeremy Anderson, Nicole D. MacIntosh, Bradley J. Front Neurosci Neuroscience Cognitive decline is often undetectable in the early stages of accelerated vascular aging. Attentional processes are particularly affected in older adults with white matter hyperintensities (WMH), although specific neurovascular mechanisms have not been elucidated. We aimed to identify differences in attention-related neurofunctional activation and behavior between adults with and without WMH. Older adults with moderate to severe WMH (n = 18, mean age = 70 years), age-matched adults (n = 28, mean age = 72), and healthy younger adults (n = 19, mean age = 25) performed a modified flanker task during multi-echo blood oxygenation level dependent functional magnetic resonance imaging. Task-related activation was assessed using a weighted-echo approach. Healthy older adults had more widespread response and higher amplitude of activation compared to WMH adults in fronto-temporal and parietal cortices. Activation associated with processing speed was absent in the WMH group, suggesting attention-related activation deficits that may be a consequence of cerebral small vessel disease. WMH adults had greater executive contrast activation in the precuneous and posterior cingulate gyrus compared to HYA, despite no performance benefits, reinforcing the network dysfunction theory in WMH. Frontiers Media S.A. 2018-10-18 /pmc/articles/PMC6200839/ /pubmed/30405336 http://dx.doi.org/10.3389/fnins.2018.00748 Text en Copyright © 2018 Atwi, Metcalfe, Robertson, Rezmovitz, Anderson and MacIntosh. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Atwi, Sarah
Metcalfe, Arron W. S.
Robertson, Andrew D.
Rezmovitz, Jeremy
Anderson, Nicole D.
MacIntosh, Bradley J.
Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title_full Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title_fullStr Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title_full_unstemmed Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title_short Attention-Related Brain Activation Is Altered in Older Adults With White Matter Hyperintensities Using Multi-Echo fMRI
title_sort attention-related brain activation is altered in older adults with white matter hyperintensities using multi-echo fmri
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200839/
https://www.ncbi.nlm.nih.gov/pubmed/30405336
http://dx.doi.org/10.3389/fnins.2018.00748
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