Eyes-Open and Eyes-Closed Resting States With Opposite Brain Activity in Sensorimotor and Occipital Regions: Multidimensional Evidences From Machine Learning Perspective

Studies have demonstrated that there are widespread significant differences in spontaneous brain activity between eyes-open (EO) and eyes-closed (EC) resting states. However, it remains largely unclear whether spontaneous brain activity is effectively related to EO and EC resting states. The amplitude, local functional concordance, inter-hemisphere functional synchronization, and network centrality of spontaneous brain activity were measured by the fraction amplitude of low frequency fluctuation (fALFF), regional homogeneity (ReHo), voxel-mirrored homotopic connectivity (VMHC) and degree centrality (DC), respectively. Using the public Eyes-open/Eyes-closed dataset, we employed the support vector machine (SVM) and bootstrap technique to establish linking models for the fALFF, ReHo, VMHC and DC dimensions. The classification accuracies of linking models are 0.72 (0.59, 0.82), 0.88 (0.79, 0.97), 0.82 (0.74, 0.91) and 0.70 (0.62, 0.79), respectively. Specifically, we observed that brain activity in the EO condition is significantly greater in attentional system areas, including the fusiform gyrus, occipital and parietal cortex, but significantly lower in sensorimotor system areas, including the precentral/postcentral gyrus, paracentral lobule (PCL) and temporal cortex compared to the EC condition from the four dimensions. The results consistently indicated that spontaneous brain activity is effectively related to EO and EC resting states, and the two resting states are of opposite brain activity in sensorimotor and occipital regions. It may provide new insight into the neural substrate of the resting state and help computational neuroscientists or neuropsychologists to choose an appropriate resting state condition to investigate various mental disorders from the resting state functional magnetic resonance imaging (fMRI) technique.