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Interplay of ancestral non-primate lentiviruses with the virus-restricting SAMHD1 proteins of their hosts

Lentiviruses infect both dividing CD4(+) T cells and nondividing myeloid cells, and the infected myeloid cells serve as long-living viral reservoirs. Host sterile alpha motif– and histidine-aspartate domain–containing protein 1 (SAMHD1) kinetically restricts reverse transcription of primate lentivir...

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Detalles Bibliográficos
Autores principales:	Mereby, Sarah A., Maehigashi, Tatsuya, Holler, Jessica M., Kim, Dong-Hyun, Schinazi, Raymond F., Kim, Baek
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2018
Materias:	Microbiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6200947/ https://www.ncbi.nlm.nih.gov/pubmed/30181218 http://dx.doi.org/10.1074/jbc.RA118.004567

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