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Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models

Alpha toxin (AT) is a cytolytic pore-forming toxin that plays a key role in Staphylococcus aureus pathogenesis; consequently, extensive research was undertaken to understand the AT mechanism of action and its utility as a target for novel prophylaxis and treatment strategies against S. aureus infect...

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Detalles Bibliográficos
Autores principales:	Tkaczyk, C., Semenova, E., Shi, Y. Y., Rosenthal, K., Oganesyan, V., Warrener, P., Stover, C. K., Sellman, B. R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Clinical Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201083/ https://www.ncbi.nlm.nih.gov/pubmed/30150481 http://dx.doi.org/10.1128/AAC.01033-18

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