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Can We Improve Stavudine's Safety Profile in Children? Pharmacokinetics of Intracellular Stavudine Triphosphate with Reduced Dosing

Stavudine remains a useful replacement option for treatment for HIV(+) children. WHO reduced the adult dose to 30 mg twice daily, which maintains efficacy and lowers mitochondrial toxicity. We explored intracellular stavudine triphosphate levels in children receiving a reduced dose of 0.5 to 0.75 mg...

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Detalles Bibliográficos
Autores principales:	Innes, Steve, van der Laan, Louvina, Anderson, Peter L., Cotton, Mark, Denti, Paolo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2018
Materias:	Antiviral Agents
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201115/ https://www.ncbi.nlm.nih.gov/pubmed/30104267 http://dx.doi.org/10.1128/AAC.00761-18

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