Absence of cannabinoid 1 receptor in beta cells protects against high-fat/high-sugar diet-induced beta cell dysfunction and inflammation in murine islets

AIMS/HYPOTHESIS: The cannabinoid 1 receptor (CB1R) regulates insulin sensitivity and glucose metabolism in peripheral tissues. CB1R is expressed on pancreatic beta cells and is coupled to the G protein Gαi, suggesting a negative regulation of endogenous signalling in the beta cell. Deciphering the e...

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Detalles Bibliográficos
Autores principales: González-Mariscal, Isabel, Montoro, Rodrigo A., Doyle, Máire E., Liu, Qing-Rong, Rouse, Michael, O’Connell, Jennifer F., Santa-Cruz Calvo, Sara, Krzysik-Walker, Susan M., Ghosh, Soumita, Carlson, Olga D., Lehrmann, Elin, Zhang, Yongqing, Becker, Kevin G., Chia, Chee W., Ghosh, Paritosh, Egan, Josephine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201315/
https://www.ncbi.nlm.nih.gov/pubmed/29497784
http://dx.doi.org/10.1007/s00125-018-4576-4

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