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A Membrane Potential- and Calpain-Dependent Reversal of Caspase-1 Inhibition Regulates Canonical NLRP3 Inflammasome

The NLRP3 inflammasome senses a range of cellular disturbances, although no consensus exists regarding a common mechanism. Canonical NLRP3 activation is blocked by high extracellular K(+), regardless of the activating signal. We report here that canonical NLRP3 activation leads to Ca(2+) flux and in...

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Detalles Bibliográficos
Autores principales:	Zhang, Yifei, Rong, Hua, Zhang, Fang-Xiong, Wu, Kun, Mu, Libing, Meng, Junchen, Xiao, Bailong, Zamponi, Gerald W., Shi, Yan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201321/ https://www.ncbi.nlm.nih.gov/pubmed/30157429 http://dx.doi.org/10.1016/j.celrep.2018.07.098

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