A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature

Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. We report a case of a 58-year-old male...

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Detalles Bibliográficos
Autores principales: Schoninger, Scott, Homsi, Yamen, Kreps, Alexandra, Milojkvovic, Natasa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201338/
https://www.ncbi.nlm.nih.gov/pubmed/30405932
http://dx.doi.org/10.1155/2018/9746241
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author Schoninger, Scott
Homsi, Yamen
Kreps, Alexandra
Milojkvovic, Natasa
author_facet Schoninger, Scott
Homsi, Yamen
Kreps, Alexandra
Milojkvovic, Natasa
author_sort Schoninger, Scott
collection PubMed
description Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. We report a case of a 58-year-old male who presented with symmetrical inflammatory polyarthritis and was misdiagnosed with seronegative rheumatoid arthritis (RA). After failing many RA treatments and with further workup, the diagnosis of MM was made. This rare manifestation of MM carries a diagnostic challenge and causes a significant delay in treating such patients. Here, we report this unusual initial presentation with review of several cases in the English literature describing similar presentations.
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spelling pubmed-62013382018-11-07 A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature Schoninger, Scott Homsi, Yamen Kreps, Alexandra Milojkvovic, Natasa Case Rep Rheumatol Case Report Multiple myeloma (MM) is a malignant plasma cell proliferation producing large numbers of monoclonal immunoglobulins. Typical MM symptoms include anemia, renal failure, hypercalcemia, and bone pain. Atypical symptoms have rarely been reported in the literature. We report a case of a 58-year-old male who presented with symmetrical inflammatory polyarthritis and was misdiagnosed with seronegative rheumatoid arthritis (RA). After failing many RA treatments and with further workup, the diagnosis of MM was made. This rare manifestation of MM carries a diagnostic challenge and causes a significant delay in treating such patients. Here, we report this unusual initial presentation with review of several cases in the English literature describing similar presentations. Hindawi 2018-10-11 /pmc/articles/PMC6201338/ /pubmed/30405932 http://dx.doi.org/10.1155/2018/9746241 Text en Copyright © 2018 Scott Schoninger et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Schoninger, Scott
Homsi, Yamen
Kreps, Alexandra
Milojkvovic, Natasa
A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title_full A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title_fullStr A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title_full_unstemmed A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title_short A Case of Multiple Myeloma Misdiagnosed as Seronegative Rheumatoid Arthritis and Review of Relevant Literature
title_sort case of multiple myeloma misdiagnosed as seronegative rheumatoid arthritis and review of relevant literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201338/
https://www.ncbi.nlm.nih.gov/pubmed/30405932
http://dx.doi.org/10.1155/2018/9746241
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