The roles of TNFAIP2 in cancers and infectious diseases

TNFα‐induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF‐κB, KLF5 and retinoic acid. Physiologically, TNFAIP...

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Detalles Bibliográficos
Autores principales: Jia, Lin, Shi, Yundong, Wen, Yi, Li, Wei, Feng, Jing, Chen, Ceshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201362/
https://www.ncbi.nlm.nih.gov/pubmed/30145807
http://dx.doi.org/10.1111/jcmm.13822
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author Jia, Lin
Shi, Yundong
Wen, Yi
Li, Wei
Feng, Jing
Chen, Ceshi
author_facet Jia, Lin
Shi, Yundong
Wen, Yi
Li, Wei
Feng, Jing
Chen, Ceshi
author_sort Jia, Lin
collection PubMed
description TNFα‐induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF‐κB, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer.
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spelling pubmed-62013622018-11-01 The roles of TNFAIP2 in cancers and infectious diseases Jia, Lin Shi, Yundong Wen, Yi Li, Wei Feng, Jing Chen, Ceshi J Cell Mol Med Reviews TNFα‐induced protein 2 (TNFAIP2) is a primary response gene of TNFα. TNFAIP2 is highly expressed in immune cells and the urinary bladder. The expression of TNFAIP2 is regulated by multiple transcription factors and signalling pathways, including NF‐κB, KLF5 and retinoic acid. Physiologically, TNFAIP2 appears to be a multiple functional mediator not only for inflammation, angiogenesis and tunneling nanotube (TNT) formation but also as a regulator of cell proliferation and migration. The expression of TNFAIP2 is frequently abnormal in human cancers and in infectious diseases. Due to its significant functions in cell proliferation, angiogenesis, migration and invasion, TNFAIP2 could be a potential diagnostic biomarker and therapeutic target for cancer. John Wiley and Sons Inc. 2018-08-25 2018-11 /pmc/articles/PMC6201362/ /pubmed/30145807 http://dx.doi.org/10.1111/jcmm.13822 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Jia, Lin
Shi, Yundong
Wen, Yi
Li, Wei
Feng, Jing
Chen, Ceshi
The roles of TNFAIP2 in cancers and infectious diseases
title The roles of TNFAIP2 in cancers and infectious diseases
title_full The roles of TNFAIP2 in cancers and infectious diseases
title_fullStr The roles of TNFAIP2 in cancers and infectious diseases
title_full_unstemmed The roles of TNFAIP2 in cancers and infectious diseases
title_short The roles of TNFAIP2 in cancers and infectious diseases
title_sort roles of tnfaip2 in cancers and infectious diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201362/
https://www.ncbi.nlm.nih.gov/pubmed/30145807
http://dx.doi.org/10.1111/jcmm.13822
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