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CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial infiltration of various inflammatory cells. Chemokines are involved in controlling the recruitment of different cell types into the synovial membrane. The role of CCR6 in the development of arthritis so...

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Autores principales: Bonelli, Michael, Puchner, Antonia, Göschl, Lisa, Hayer, Silvia, Niederreiter, Birgit, Steiner, Guenter, Tillmann, Katharina, Plasenzotti, Roberto, Podesser, Bruno, Georgel, Philippe, Smolen, Josef, Scheinecker, Clemens, Blüml, Stephan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201376/
https://www.ncbi.nlm.nih.gov/pubmed/30133119
http://dx.doi.org/10.1111/jcmm.13783
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author Bonelli, Michael
Puchner, Antonia
Göschl, Lisa
Hayer, Silvia
Niederreiter, Birgit
Steiner, Guenter
Tillmann, Katharina
Plasenzotti, Roberto
Podesser, Bruno
Georgel, Philippe
Smolen, Josef
Scheinecker, Clemens
Blüml, Stephan
author_facet Bonelli, Michael
Puchner, Antonia
Göschl, Lisa
Hayer, Silvia
Niederreiter, Birgit
Steiner, Guenter
Tillmann, Katharina
Plasenzotti, Roberto
Podesser, Bruno
Georgel, Philippe
Smolen, Josef
Scheinecker, Clemens
Blüml, Stephan
author_sort Bonelli, Michael
collection PubMed
description Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial infiltration of various inflammatory cells. Chemokines are involved in controlling the recruitment of different cell types into the synovial membrane. The role of CCR6 in the development of arthritis so far remains unclear. In this study, we investigated the role of CCR6 in the pathogenesis of arthritis using three different murine arthritis models. Compared to WT animals, CCR6 (−/−) mice developed less clinical signs of arthritis in the collagen‐induced arthritis model but not in the K/BxN serum transfer arthritis model and in the human tumour necrosis factor transgenic arthritis model, suggesting a defect in adaptive effector functions but intact innate effector functions in the development of arthritis in CCR6 (−/−) animals. In line with this, anti‐collagen antibody levels were significantly reduced in CCR6 (−/−) mice compared with WT mice. Moreover, we demonstrate enhanced osteoclastogenesis in vitro in CCR6 (−/−) mice compared with WT mice. However, we did not detect differences in bone mass under steady state conditions in vivo between WT and CCR6‐deficient mice. These data suggest that CCR6 is crucially involved in adaptive but not in innate immunity‐driven arthritis. CCR6 or its chemokine ligand CCL20 might represent a possible new target for the treatment of RA.
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spelling pubmed-62013762018-11-01 CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis Bonelli, Michael Puchner, Antonia Göschl, Lisa Hayer, Silvia Niederreiter, Birgit Steiner, Guenter Tillmann, Katharina Plasenzotti, Roberto Podesser, Bruno Georgel, Philippe Smolen, Josef Scheinecker, Clemens Blüml, Stephan J Cell Mol Med Original Articles Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease, characterized by synovial infiltration of various inflammatory cells. Chemokines are involved in controlling the recruitment of different cell types into the synovial membrane. The role of CCR6 in the development of arthritis so far remains unclear. In this study, we investigated the role of CCR6 in the pathogenesis of arthritis using three different murine arthritis models. Compared to WT animals, CCR6 (−/−) mice developed less clinical signs of arthritis in the collagen‐induced arthritis model but not in the K/BxN serum transfer arthritis model and in the human tumour necrosis factor transgenic arthritis model, suggesting a defect in adaptive effector functions but intact innate effector functions in the development of arthritis in CCR6 (−/−) animals. In line with this, anti‐collagen antibody levels were significantly reduced in CCR6 (−/−) mice compared with WT mice. Moreover, we demonstrate enhanced osteoclastogenesis in vitro in CCR6 (−/−) mice compared with WT mice. However, we did not detect differences in bone mass under steady state conditions in vivo between WT and CCR6‐deficient mice. These data suggest that CCR6 is crucially involved in adaptive but not in innate immunity‐driven arthritis. CCR6 or its chemokine ligand CCL20 might represent a possible new target for the treatment of RA. John Wiley and Sons Inc. 2018-08-22 2018-11 /pmc/articles/PMC6201376/ /pubmed/30133119 http://dx.doi.org/10.1111/jcmm.13783 Text en © 2018 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Bonelli, Michael
Puchner, Antonia
Göschl, Lisa
Hayer, Silvia
Niederreiter, Birgit
Steiner, Guenter
Tillmann, Katharina
Plasenzotti, Roberto
Podesser, Bruno
Georgel, Philippe
Smolen, Josef
Scheinecker, Clemens
Blüml, Stephan
CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title_full CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title_fullStr CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title_full_unstemmed CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title_short CCR6 controls autoimmune but not innate immunity‐driven experimental arthritis
title_sort ccr6 controls autoimmune but not innate immunity‐driven experimental arthritis
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201376/
https://www.ncbi.nlm.nih.gov/pubmed/30133119
http://dx.doi.org/10.1111/jcmm.13783
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