Reversal of Aging‐Induced Increases in Aortic Stiffness by Targeting Cytoskeletal Protein‐Protein Interfaces

BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole. This shock absorber function is impaired with age because of aortic stiffening. METHODS AND RESULT...

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Detalles Bibliográficos
Autores principales: Nicholson, Christopher J., Singh, Kuldeep, Saphirstein, Robert J., Gao, Yuan Z., Li, Qian, Chiu, Joanna G., Leavis, Paul, Verwoert, Germaine C., Mitchell, G. F., Porter, Tyrone, Morgan, Kathleen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201469/
https://www.ncbi.nlm.nih.gov/pubmed/30021807
http://dx.doi.org/10.1161/JAHA.118.008926

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