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Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study

BACKGROUND: Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to...

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Autores principales: Kubesch, Nadine J., Therming Jørgensen, Jeanette, Hoffmann, Barbara, Loft, Steffen, Nieuwenhuijsen, Mark J., Raaschou‐Nielsen, Ole, Pedersen, Marie, Hertel, Ole, Overvad, Kim, Tjønneland, Anne, Prescot, Eva, Andersen, Zorana J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201474/
https://www.ncbi.nlm.nih.gov/pubmed/30021805
http://dx.doi.org/10.1161/JAHA.118.009554
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author Kubesch, Nadine J.
Therming Jørgensen, Jeanette
Hoffmann, Barbara
Loft, Steffen
Nieuwenhuijsen, Mark J.
Raaschou‐Nielsen, Ole
Pedersen, Marie
Hertel, Ole
Overvad, Kim
Tjønneland, Anne
Prescot, Eva
Andersen, Zorana J.
author_facet Kubesch, Nadine J.
Therming Jørgensen, Jeanette
Hoffmann, Barbara
Loft, Steffen
Nieuwenhuijsen, Mark J.
Raaschou‐Nielsen, Ole
Pedersen, Marie
Hertel, Ole
Overvad, Kim
Tjønneland, Anne
Prescot, Eva
Andersen, Zorana J.
author_sort Kubesch, Nadine J.
collection PubMed
description BACKGROUND: Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic‐related air pollution. METHODS AND RESULTS: A group of 57 053 participants (50–65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993–1997) and were linked to registry data on hospital contacts and out‐of‐hospital deaths caused by MI, until December 2015. Nitrogen dioxide levels were estimated at participants’ baseline residences. We used Cox regressions to associate participation in sports, cycling, walking, and gardening with incident and recurrent MI, and tested for interaction by nitrogen dioxide. Of 50 635 participants without MI at baseline, 2936 developed incident MI, and of 1233 participants with MI before baseline, 324 had recurring MI during follow‐up. Mean nitrogen dioxide concentration was 18.7 μg/m(3) at baseline (1993–1997). We found inverse statistically significant associations between participation in sports (hazard ratio; 95% confidence interval: 0.85; 0.79–0.92), cycling (0.91; 0.84–0.98), gardening (0.87; 0.80–0.95), and incident MI, while the association with walking was statistically nonsignificant (0.95; 0.83–1.08). Recurrent MI was statistically nonsignificantly inversely associated with cycling (0.80; 0.63–1.02), walking (0.82, 0.57–1.16), and gardening (0.91; 0.71–1.18), and positively with sports (1.06; 0.83–1.35). There was no effect modification of the associations between physical activity and MI by nitrogen dioxide. CONCLUSIONS: Benefits of physical activity on both the incidence and the recurrence of MI are not reduced by exposure to high levels of air pollution.
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spelling pubmed-62014742018-10-31 Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study Kubesch, Nadine J. Therming Jørgensen, Jeanette Hoffmann, Barbara Loft, Steffen Nieuwenhuijsen, Mark J. Raaschou‐Nielsen, Ole Pedersen, Marie Hertel, Ole Overvad, Kim Tjønneland, Anne Prescot, Eva Andersen, Zorana J. J Am Heart Assoc Original Research BACKGROUND: Physical activity enhances the uptake of air pollutants, possibly reducing its beneficial effects. We examined the effects of leisure‐time and transport‐related physical activities on the risk of myocardial infarction (MI), and whether potential benefits on MI are reduced by exposure to traffic‐related air pollution. METHODS AND RESULTS: A group of 57 053 participants (50–65 years of age) from the Danish Diet, Cancer, and Health cohort reported physical activity at baseline (1993–1997) and were linked to registry data on hospital contacts and out‐of‐hospital deaths caused by MI, until December 2015. Nitrogen dioxide levels were estimated at participants’ baseline residences. We used Cox regressions to associate participation in sports, cycling, walking, and gardening with incident and recurrent MI, and tested for interaction by nitrogen dioxide. Of 50 635 participants without MI at baseline, 2936 developed incident MI, and of 1233 participants with MI before baseline, 324 had recurring MI during follow‐up. Mean nitrogen dioxide concentration was 18.7 μg/m(3) at baseline (1993–1997). We found inverse statistically significant associations between participation in sports (hazard ratio; 95% confidence interval: 0.85; 0.79–0.92), cycling (0.91; 0.84–0.98), gardening (0.87; 0.80–0.95), and incident MI, while the association with walking was statistically nonsignificant (0.95; 0.83–1.08). Recurrent MI was statistically nonsignificantly inversely associated with cycling (0.80; 0.63–1.02), walking (0.82, 0.57–1.16), and gardening (0.91; 0.71–1.18), and positively with sports (1.06; 0.83–1.35). There was no effect modification of the associations between physical activity and MI by nitrogen dioxide. CONCLUSIONS: Benefits of physical activity on both the incidence and the recurrence of MI are not reduced by exposure to high levels of air pollution. John Wiley and Sons Inc. 2018-07-18 /pmc/articles/PMC6201474/ /pubmed/30021805 http://dx.doi.org/10.1161/JAHA.118.009554 Text en © 2018 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Original Research
Kubesch, Nadine J.
Therming Jørgensen, Jeanette
Hoffmann, Barbara
Loft, Steffen
Nieuwenhuijsen, Mark J.
Raaschou‐Nielsen, Ole
Pedersen, Marie
Hertel, Ole
Overvad, Kim
Tjønneland, Anne
Prescot, Eva
Andersen, Zorana J.
Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title_full Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title_fullStr Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title_full_unstemmed Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title_short Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study
title_sort effects of leisure‐time and transport‐related physical activities on the risk of incident and recurrent myocardial infarction and interaction with traffic‐related air pollution: a cohort study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201474/
https://www.ncbi.nlm.nih.gov/pubmed/30021805
http://dx.doi.org/10.1161/JAHA.118.009554
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