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Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study

BACKGROUND: The utility of pulmonary artery catheters (PACs) and their measurements depend on a variety of factors including data interpretation and personnel training. This US multi-center, retrospective electronic health record (EHR) database analysis was performed to identify associations between...

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Autores principales: Shaw, Andrew D., Mythen, Michael G., Shook, Douglas, Hayashida, David K., Zhang, Xuan, Skaar, Jeffrey R., Iyengar, Sloka S., Munson, Sibyl H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201566/
https://www.ncbi.nlm.nih.gov/pubmed/30386591
http://dx.doi.org/10.1186/s13741-018-0103-x
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author Shaw, Andrew D.
Mythen, Michael G.
Shook, Douglas
Hayashida, David K.
Zhang, Xuan
Skaar, Jeffrey R.
Iyengar, Sloka S.
Munson, Sibyl H.
author_facet Shaw, Andrew D.
Mythen, Michael G.
Shook, Douglas
Hayashida, David K.
Zhang, Xuan
Skaar, Jeffrey R.
Iyengar, Sloka S.
Munson, Sibyl H.
author_sort Shaw, Andrew D.
collection PubMed
description BACKGROUND: The utility of pulmonary artery catheters (PACs) and their measurements depend on a variety of factors including data interpretation and personnel training. This US multi-center, retrospective electronic health record (EHR) database analysis was performed to identify associations between PAC use in adult cardiac surgeries and effects on subsequent clinical outcomes. METHODS: This cohort analysis utilized the Cerner Health Facts database to examine patients undergoing isolated coronary artery bypass graft (CABG), isolated valve surgery, aortic surgery, other complex non-valvular and multi-cardiac procedures, and/or heart transplant from January 1, 2011, to June 30, 2015. A total of 6844 adults in two cohorts, each with 3422 patients who underwent a qualifying cardiac procedure with or without the use of a PAC for monitoring purposes, were included. Patients were matched 1:1 using a propensity score based upon the date and type of surgery, hospital demographics, modified European System for Cardiac Operative Risk Evaluation (EuroSCORE II), and patient characteristics. Primary outcomes of 30-day in-hospital mortality, length of stay, cardiopulmonary morbidity, and infectious morbidity were analyzed after risk adjustment for acute physiology score. RESULTS: There was no difference in the 30-day in-hospital mortality rate between treatment groups (OR, 1.17; 95% CI, 0.65–2.10; p = 0.516). PAC use was associated with a decreased length of stay (9.39 days without a PAC vs. 8.56 days with PAC; p < 0.001), a decreased cardiopulmonary morbidity (OR, 0.87; 95% CI, 0.79–0.96; p < 0.001), and an increased infectious morbidity (OR, 1.28; 95% CI, 1.10–1.49; p < 0.001). CONCLUSIONS: Use of a PAC during adult cardiac surgery is associated with decreased length of stay, reduced cardiopulmonary morbidity, and increased infectious morbidity but no increase in the 30-day in-hospital mortality. This suggests an overall potential benefit associated with PAC-based monitoring in this population. TRIAL REGISTRATION: The study was registered at clinicaltrials.gov (NCT02964026) on November 15, 2016. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13741-018-0103-x) contains supplementary material, which is available to authorized users.
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spelling pubmed-62015662018-10-31 Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study Shaw, Andrew D. Mythen, Michael G. Shook, Douglas Hayashida, David K. Zhang, Xuan Skaar, Jeffrey R. Iyengar, Sloka S. Munson, Sibyl H. Perioper Med (Lond) Research BACKGROUND: The utility of pulmonary artery catheters (PACs) and their measurements depend on a variety of factors including data interpretation and personnel training. This US multi-center, retrospective electronic health record (EHR) database analysis was performed to identify associations between PAC use in adult cardiac surgeries and effects on subsequent clinical outcomes. METHODS: This cohort analysis utilized the Cerner Health Facts database to examine patients undergoing isolated coronary artery bypass graft (CABG), isolated valve surgery, aortic surgery, other complex non-valvular and multi-cardiac procedures, and/or heart transplant from January 1, 2011, to June 30, 2015. A total of 6844 adults in two cohorts, each with 3422 patients who underwent a qualifying cardiac procedure with or without the use of a PAC for monitoring purposes, were included. Patients were matched 1:1 using a propensity score based upon the date and type of surgery, hospital demographics, modified European System for Cardiac Operative Risk Evaluation (EuroSCORE II), and patient characteristics. Primary outcomes of 30-day in-hospital mortality, length of stay, cardiopulmonary morbidity, and infectious morbidity were analyzed after risk adjustment for acute physiology score. RESULTS: There was no difference in the 30-day in-hospital mortality rate between treatment groups (OR, 1.17; 95% CI, 0.65–2.10; p = 0.516). PAC use was associated with a decreased length of stay (9.39 days without a PAC vs. 8.56 days with PAC; p < 0.001), a decreased cardiopulmonary morbidity (OR, 0.87; 95% CI, 0.79–0.96; p < 0.001), and an increased infectious morbidity (OR, 1.28; 95% CI, 1.10–1.49; p < 0.001). CONCLUSIONS: Use of a PAC during adult cardiac surgery is associated with decreased length of stay, reduced cardiopulmonary morbidity, and increased infectious morbidity but no increase in the 30-day in-hospital mortality. This suggests an overall potential benefit associated with PAC-based monitoring in this population. TRIAL REGISTRATION: The study was registered at clinicaltrials.gov (NCT02964026) on November 15, 2016. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s13741-018-0103-x) contains supplementary material, which is available to authorized users. BioMed Central 2018-10-25 /pmc/articles/PMC6201566/ /pubmed/30386591 http://dx.doi.org/10.1186/s13741-018-0103-x Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Shaw, Andrew D.
Mythen, Michael G.
Shook, Douglas
Hayashida, David K.
Zhang, Xuan
Skaar, Jeffrey R.
Iyengar, Sloka S.
Munson, Sibyl H.
Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title_full Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title_fullStr Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title_full_unstemmed Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title_short Pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
title_sort pulmonary artery catheter use in adult patients undergoing cardiac surgery: a retrospective, cohort study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201566/
https://www.ncbi.nlm.nih.gov/pubmed/30386591
http://dx.doi.org/10.1186/s13741-018-0103-x
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