Cargando…

A first-in-human, randomized, double-blind, placebo-controlled, single and multiple ascending oral dose study to assess the safety, tolerability, and pharmacokinetics of BZF961 with and without ritonavir in healthy adult volunteers

Objective: Infection with hepatitis C virus is the leading indication for liver transplantation and most common cause of infectious disease-related mortality in the United States. BZF961 is a novel inhibitor of the hepatitis C virus NS3-4A protease. Methods: This sequential, three part exploratory f...

Descripción completa

Detalles Bibliográficos
Autores principales:	Youngberg, Stephen, Brandt, Erin, Barve, Avantika, Machineni, Surendra, Jones, Christopher T., Dabovic, Kristina, Jones, Catherine L., Colvin, Richard A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2018
Materias:	Infectious Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201795/ https://www.ncbi.nlm.nih.gov/pubmed/30370176 http://dx.doi.org/10.1080/21556660.2018.1535438

Ejemplares similares

Preventing Cushing: Iatrogenic Cushing Syndrome due to Ritonavir-Fluticasone Interaction
por: Tiruneh, Fasil, et al.
Publicado: (2017)

Adverse effects of remdesivir, hydroxychloroquine and lopinavir/ritonavir when used for COVID-19: systematic review and meta-analysis of randomised trials
por: Izcovich, Ariel, et al.
Publicado: (2022)

Understanding paratyphoid infection: study protocol for the development of a human model of Salmonella enterica serovar Paratyphi A challenge in healthy adult volunteers
por: McCullagh, David, et al.
Publicado: (2015)

Pharmacokinetic Interaction Between Prasugrel and Ritonavir in Healthy Volunteers
por: Ancrenaz, Virginie, et al.
Publicado: (2013)

Accelerating clinical development of a live attenuated vaccine against Salmonella Paratyphi A (VASP): study protocol for an observer-participant-blind randomised control trial of a novel oral vaccine using a human challenge model of Salmonella Paratyphi A infection in healthy adult volunteers
por: McCann, Naina, et al.
Publicado: (2023)

Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19
por: Bosaeed, Mohammad, et al.
Publicado: (2021)

Chlorhexidine oral rinses for symptomatic COPD: a randomised, blind, placebo-controlled preliminary study
por: Pragman, Alexa A, et al.
Publicado: (2021)

The effect of simvastatin on inflammatory cytokines in community-acquired pneumonia: a randomised, double-blind, placebo-controlled trial
por: Viasus, Diego, et al.
Publicado: (2015)

Early use of Antibiotics for at Risk CHildren with InfluEnza (ARCHIE): protocol for a double-blind, randomised, placebo-controlled trial
por: Wang, Kay, et al.
Publicado: (2018)

Prospective observational study on the pharmacokinetic properties of the Irrua ribavirin regimen used in routine clinical practice in patients with Lassa fever in Nigeria
por: Erameh, Cyril, et al.
Publicado: (2020)

Fatality Rate and Survival Time of Laboratory-Confirmed COVID-19 for Patients in England During the First Wave of SARS-CoV-2 Infection: A Modelling Study
por: Hillyar, Christopher R, et al.
Publicado: (2021)

Faecal microbiota transplant to ERadicate gastrointestinal carriage of Antibiotic Resistant Organisms (FERARO): a prospective, randomised placebo-controlled feasibility trial
por: Merrick, Blair, et al.
Publicado: (2020)

Optimisation of treatments for oral Neisseria gonorrhoeae infection: Pharmacokinetics Study (STI-PK project) – study protocol for non-randomised clinical trial
por: Kong, Fabian Y S, et al.
Publicado: (2022)

Multicentre randomised double-blind placebo controlled trial of combination vancomycin and cefazolin surgical antibiotic prophylaxis: the Australian surgical antibiotic prophylaxis (ASAP) trial
por: Peel, Trisha, et al.
Publicado: (2019)

Randomised, double-blind, placebo-controlled trial of Probiotics To Eliminate COVID-19 Transmission in Exposed Household Contacts (PROTECT-EHC): a clinical trial protocol
por: Tang, Helen, et al.
Publicado: (2021)

Low-dose trimethoprim-sulfamethoxazole for the treatment of Pneumocystis jirovecii pneumonia (LOW-TMP): protocol for a phase III randomised, placebo-controlled, dose-comparison trial
por: Sohani, Zahra N., et al.
Publicado: (2022)

Levofloxacin versus placebo for the treatment of latent tuberculosis among contacts of patients with multidrug-resistant tuberculosis (the VQUIN MDR trial): a protocol for a randomised controlled trial
por: Fox, Greg J, et al.
Publicado: (2020)

Raoultella Planticola: Bacteremia and Sepsis in a Patient with Cirrhosis
por: Povlow, Michael R, et al.
Publicado: (2017)

Salmonella Vaccine Study in Oxford (SALVO) trial: protocol for an observer-participant blind randomised placebo-controlled trial of the iNTS-GMMA vaccine within a European cohort
por: Hanumunthadu, Brama, et al.
Publicado: (2023)

Safety and pharmacokinetics-pharmacodynamics of a shorter tuberculosis treatment with high-dose pyrazinamide and rifampicin: a study protocol of a phase II clinical trial (HighShort-RP)
por: Ekqvist, David, et al.
Publicado: (2022)

Group IIA secretory phospholipase 2 independently predicts mortality and positive blood culture in emergency department sepsis patients
por: Nandi, Utsav, et al.
Publicado: (2021)

Proxalutamide Significantly Accelerates Viral Clearance and Reduces Time to Clinical Remission in Patients with Mild to Moderate COVID-19: Results from a Randomized, Double-Blinded, Placebo-Controlled Trial
por: Cadegiani, Flavio A, et al.
Publicado: (2021)

Randomised, double-blind, placebo-controlled, phase 2, superiority trial to demonstrate the effectiveness of faecal microbiota transplantation for selective intestinal decolonisation of patients colonised by carbapenemase-producing Klebsiella pneumoniae (KAPEDIS)
por: Pérez-Nadales, Elena, et al.
Publicado: (2022)

EPOS trial: the effect of air filtration through a plasma chamber on the incidence of surgical site infection in orthopaedic surgery: a study protocol of a randomised, double-blind, placebo-controlled trial
por: Persson, Anders, et al.
Publicado: (2022)

ARCADIA study protocol: a phase II, randomised, double-blind, placebo-controlled clinical trial to assess the safety and efficacy of AZD1656 in patients with diabetes hospitalised with suspected or confirmed COVID-19
por: McCafferty, Kieran, et al.
Publicado: (2021)

A randomized, double-blind study on the efficacy of oral domperidone versus placebo for reducing SARS-CoV-2 viral load in mild-to-moderate COVID-19 patients in primary health care
por: Rabanal Basalo, Alejandro, et al.
Publicado: (2023)

A Review of the Value of Procalcitonin as a Marker of Infection
por: Taylor, Richard, et al.
Publicado: (2017)

Low BALF CD4 T cells count is associated with extubation failure and mortality in critically ill covid-19 pneumonia
por: Singh, Gurmeet, et al.
Publicado: (2022)

Efficacy and safety of a triple active sore throat lozenge in the treatment of patients with acute pharyngitis: Results of a multi‐centre, randomised, placebo‐controlled, double‐blind, parallel‐group trial (DoriPha)
por: Palm, Jürgen, et al.
Publicado: (2018)

Study protocol for controlled human infection for penicillin G against Streptococcus pyogenes: a double-blinded, placebo-controlled, randomised trial to determine the minimum concentration required to prevent experimental pharyngitis (the CHIPS trial)
por: Hla, Thel Khin, et al.
Publicado: (2022)

Biomarkers and outcomes in hospitalised patients with COVID-19: a prospective registry
por: Khedar, Raghubir Singh, et al.
Publicado: (2022)

Donor-derived Transmission of Hepatitis A Virus Following Kidney Transplantation: Clinical Course of Two Cases From One Donor
por: Jones, Jefferson M., et al.
Publicado: (2023)

Antibiotic use and clinical outcomes in the acute setting under management by an infectious diseases acute physician versus other clinical teams: a cohort study
por: Fawcett, Nicola JK, et al.
Publicado: (2016)

Antibiotic prescribing in neonatal sepsis: an Australian nationwide survey
por: McMullan, Brendan, et al.
Publicado: (2020)

Controlled human infection with Neisseria lactamica in late pregnancy to measure horizontal transmission and microbiome changes in mother–neonate pairs: a single-arm interventional pilot study protocol
por: Theodosiou, Anastasia A, et al.
Publicado: (2022)

Population pharmacokinetics of ritonavir-boosted atazanavir in HIV-infected patients and healthy volunteers
por: Dickinson, Laura, et al.
Publicado: (2009)

Factors influencing women's attitudes towards antenatal vaccines, group B Streptococcus and clinical trial participation in pregnancy: an online survey
por: McQuaid, Fiona, et al.
Publicado: (2016)

Randomised controlled trial for high-dose intravenous zinc as adjunctive therapy in SARS-CoV-2 (COVID-19) positive critically ill patients: trial protocol
por: Perera, Marlon, et al.
Publicado: (2020)

Long-term outcomes of urinary tract infection (UTI) in Childhood (LUCI): protocol for an electronic record-linked cohort study
por: Lugg-Widger, Fiona V, et al.
Publicado: (2019)

Non‐targeted hepatitis C virus screening in acute care healthcare settings in the Southern Appalachian region
por: Chastain, Cody A., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_4ptao857tjqblfq0cggkcssn0e