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RNA Polymerase II Phosphorylated on CTD Serine 5 Interacts with the Spliceosome during Co-transcriptional Splicing

The highly intronic nature of protein coding genes in mammals necessitates a co-transcriptional splicing mechanism as revealed by mNET-seq analysis. Immunoprecipitation of MNase-digested chromatin with antibodies against RNA polymerase II (Pol II) shows that active spliceosomes (both snRNA and prote...

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Detalles Bibliográficos
Autores principales:	Nojima, Takayuki, Rebelo, Kenny, Gomes, Tomás, Grosso, Ana Rita, Proudfoot, Nicholas J., Carmo-Fonseca, Maria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201815/ https://www.ncbi.nlm.nih.gov/pubmed/30340024 http://dx.doi.org/10.1016/j.molcel.2018.09.004

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