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Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients
Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late,...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201901/ https://www.ncbi.nlm.nih.gov/pubmed/30359420 http://dx.doi.org/10.1371/journal.pone.0206051 |
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author | Sylvestre, Tatiane Fernanda Cavalcante, Ricardo de Souza da Silva, Julhiany de Fátima Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves de Carvalho, Lídia Raquel dos Santos, Lucilene Delazari Mendes, Rinaldo Poncio |
author_facet | Sylvestre, Tatiane Fernanda Cavalcante, Ricardo de Souza da Silva, Julhiany de Fátima Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves de Carvalho, Lídia Raquel dos Santos, Lucilene Delazari Mendes, Rinaldo Poncio |
author_sort | Sylvestre, Tatiane Fernanda |
collection | PubMed |
description | Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision. |
format | Online Article Text |
id | pubmed-6201901 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-62019012018-11-19 Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients Sylvestre, Tatiane Fernanda Cavalcante, Ricardo de Souza da Silva, Julhiany de Fátima Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves de Carvalho, Lídia Raquel dos Santos, Lucilene Delazari Mendes, Rinaldo Poncio PLoS One Research Article Paracoccidioidomycosis (PCM) is a systemic disease caused by thermodymorphic fungi of the Paracoccidioides brasiliensis complex, (Paracoccidioides spp.). Patients with PCM reveal specific cellular immune impairment. Despite the effective treatment, quiescent fungi can lead to relapse, usually late, the serological diagnosis of which has been deficient. The present study was carried out with the objective of investigating a biomarker for the identification of PCM relapse and another molecule behaving as an immunological recovery biomarker; therefore, it may be used as a cure criterion. In the evolutionary analysis of the proteins identified in PCM patients, comparing those that presented with those that did not reveal relapse, 29 proteins were identified. The interactions observed between the proteins, using transferrin and haptoglobin, as the main binding protein, were strong with all the others. Patient follow-up suggests that cerulosplamin may be a marker of relapse and that transferrin and apolipoprotein A-II may contribute to the evaluation of the treatment efficacy and avoiding a premature decision. Public Library of Science 2018-10-25 /pmc/articles/PMC6201901/ /pubmed/30359420 http://dx.doi.org/10.1371/journal.pone.0206051 Text en © 2018 Sylvestre et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Sylvestre, Tatiane Fernanda Cavalcante, Ricardo de Souza da Silva, Julhiany de Fátima Paniago, Anamaria Mello Miranda Weber, Simone Schneider Pauletti, Bianca Alves de Carvalho, Lídia Raquel dos Santos, Lucilene Delazari Mendes, Rinaldo Poncio Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title | Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title_full | Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title_fullStr | Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title_full_unstemmed | Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title_short | Ceruloplasmin, transferrin and apolipoprotein A-II play important role in treatment's follow-up of paracoccidioidomycosis patients |
title_sort | ceruloplasmin, transferrin and apolipoprotein a-ii play important role in treatment's follow-up of paracoccidioidomycosis patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201901/ https://www.ncbi.nlm.nih.gov/pubmed/30359420 http://dx.doi.org/10.1371/journal.pone.0206051 |
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