A synonymous RET substitution enhances the oncogenic effect of an in-cis missense mutation by increasing constitutive splicing efficiency

Synonymous mutations continue to be filtered out from most large-scale cancer genome studies, but several lines of evidence suggest they can play driver roles in neoplastic disease. We investigated a case of an aggressive, apparently sporadic medullary thyroid carcinoma (MTC) harboring a somatic RET...

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Detalles Bibliográficos
Autores principales: Pecce, Valeria, Sponziello, Marialuisa, Damante, Giuseppe, Rosignolo, Francesca, Durante, Cosimo, Lamartina, Livia, Grani, Giorgio, Russo, Diego, di Gioia, Cira Rosaria, Filetti, Sebastiano, Verrienti, Antonella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2018
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6201961/
https://www.ncbi.nlm.nih.gov/pubmed/30321177
http://dx.doi.org/10.1371/journal.pgen.1007678

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