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Detecting genome-wide directional effects of transcription factor binding on polygenic disease risk

Biological interpretation of GWAS data frequently involves assessing whether SNPs linked to a biological process, e.g., binding of a transcription factor (TF), show unsigned enrichment for disease signal. However, signed annotations quantifying whether each SNP allele promotes or hinders the biologi...

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Detalles Bibliográficos
Autores principales:	Reshef, Yakir A, Finucane, Hilary K, Kelley, David R, Gusev, Alexander, Kotliar, Dylan, Ulirsch, Jacob C, Hormozdiari, Farhad, Nasser, Joseph, O’Connor, Luke, van de Geijn, Bryce, Loh, Po-Ru, Grossman, Sharon R, Bhatia, Gaurav, Gazal, Steven, Palamara, Pier Francesco, Pinello, Luca, Patterson, Nick, Adams, Ryan P, Price, Alkes L
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202062/ https://www.ncbi.nlm.nih.gov/pubmed/30177862 http://dx.doi.org/10.1038/s41588-018-0196-7

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