Second signals rescue B cells from activation-induced mitochondrial dysfunction and death

B cells are activated by two temporally distinct signals, the first provided by antigen binding to the B cell antigen receptor (BCR) and the second by T helper cells. Here we show that B cells responded to antigen by rapidly increasing metabolic activity including both oxidative phosphorylation and...

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Detalles Bibliográficos
Autores principales: Akkaya, Munir, Traba, Javier, Roesler, Alexander S., Miozzo, Pietro, Akkaya, Billur, Theall, Brandon P., Sohn, Haewon, Pena, Mirna, Smelkinson, Margery, Kabat, Juraj, Dahlstrom, Eric, Dorward, David W., Skinner, Jeff, Sack, Michael N., Pierce, Susan K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6202187/
https://www.ncbi.nlm.nih.gov/pubmed/29988090
http://dx.doi.org/10.1038/s41590-018-0156-5

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